Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

In the plenitude of naturally occurring RNAs, circular RNAs (circRNAs) and their biological
role were underestimated for years. However, circRNAs are ubiquitous in all domains of life …

It has recently been reported that thousands of covalently linked circular RNAs (circRNAs)
are expressed from human genomes. circRNAs emerge during RNA splicing. circRNAs are …

Over the past decade, research into circular RNA (circRNA) has increased rapidly, and over
the past few years, circRNA has emerged as a promising therapeutic platform. The …

Circular RNAs are an unusual class of single-stranded RNAs whose ends are covalently
linked via back-splicing. Due to their versatility, the need to express circular RNAs in vivo …

Oligonucleotide-based therapeutics have attracted attention as an emerging modality that
includes the modulation of genes and their binding proteins related to diseases, allowing us …

Small interfering RNA (siRNA) has proved to be a powerful tool for target-specific gene
silencing via RNA interference (RNAi). Its ability to control targeted gene expression gives …

Recent successes in clinical trials have provided important proof of concept that small
interfering RNAs (siRNAs) indeed constitute a new promising class of therapeutics. Although …

Figures released in 2013 by the International Diabetes Federation (IDF) state that over 382
million individuals worldwide are affected by diabetes mellitus (DM). 1 The global …

Over the past 2 decades, different types of circular RNAs have been discovered in all
kingdoms of life, and apparently, those circular species are more abundant than previously …