The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule
cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of …

Memories become less precise and generalized over time as memory traces reorganize in
hippocampal–cortical networks. Increased time-dependent loss of memory precision is …

Millions of individuals suffer from age-related cognitive decline, defined by impaired memory
precision. Increased understanding of hippocampal circuit mechanisms underlying memory …

Aging is a process characterized by cognitive impairment and mitochondrial dysfunction. In
neurons, these organelles are classified as synaptic and non-synaptic mitochondria …

Excitatory and inhibitory neurons are connected into microcircuits that generate circuit
output. Central in the hippocampal CA3 microcircuit is the mossy fiber (MF) synapse, which …

Aging is associated with functional alterations of synapses thought to contribute to age-
dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are …

Experimental manipulations that interfere with the functional expression of N‐methyl‐d‐
aspartate receptors (NMDARs) during prenatal neurodevelopment or critical periods of …

Short-term synaptic plasticity refers to the regulation of synapses by their past activity on time
scales of milliseconds to minutes. Hippocampal mossy fiber synapses onto CA3 pyramidal …

Background Chronic brain hypoperfusion (CBH) is closely related to Alzheimer's disease
(AD) and vascular dementia (VaD). Meanwhile, synaptic pathology plays a prominent role in …

Synapse loss and altered plasticity are significant contributors to memory loss in aged
individuals. Microglia, the innate immune cells of the brain, play critical roles in maintaining …