A review of respiratory anatomical development, air flow characterization and particle deposition

MS Islam, G Paul, HX Ong, PM Young, YT Gu… - International journal of …, 2020 - mdpi.com
The understanding of complex inhalation and transport processes of pollutant particles
through the human respiratory system is important for investigations into dosimetry and …

In silico models of aerosol delivery to the respiratory tract—development and applications

PW Longest, LT Holbrook - Advanced drug delivery reviews, 2012 - Elsevier
This review discusses the application of computational models to simulate the transport and
deposition of inhaled pharmaceutical aerosols from the site of particle or droplet formation to …

Study on the coal dust deposition fraction and site in the upper respiratory tract under different particle sizes and labor intensities

Y Cheng, H Yu, S Xie, J Zhao, Y Ye - Science of The Total Environment, 2023 - Elsevier
In order to study the dust exposure amount and coal dust deposition rule of coal miners
under different labor intensity in coal mine environment, an airflow-particle two-phase …

Improved numerical simulation of aerosol deposition in an idealized mouth–throat

EA Matida, WH Finlay, CF Lange, B Grgic - Journal of aerosol science, 2004 - Elsevier
The deposition of monodisperse particles (1.0–26.0 μm diameter) in an idealized mouth–
throat geometry has been studied numerically. The continuous phase flow is solved using a …

Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway

J Xi, PW Longest - Annals of biomedical engineering, 2007 - Springer
A number of in vivo, in vitro and numerical studies have considered flow field characteristics
and micro-particle deposition in the oral airway extending from the mouth through the larynx …

Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract

F Huang, Q Zhu, X Zhou, D Gou, J Yu, R Li… - Advanced drug delivery …, 2021 - Elsevier
Effective evaluation and prediction of aerosol transport deposition in the human respiratory
tracts are critical to aerosol drug delivery and evaluation of inhalation products …

In vitro intersubject and intrasubject deposition measurements in realistic mouth–throat geometries

B Grgic, WH Finlay, PKP Burnell, AF Heenan - Journal of Aerosol Science, 2004 - Elsevier
This paper presents regional and total deposition measurements in several realistic mouth
and throat geometries and demonstrates the effects of intrasubject and intersubject …

Pulmonary aerosol transport and deposition analysis in upper 17 generations of the human respiratory tract

MS Islam, SC Saha, E Sauret, T Gemci, YT Gu - Journal of Aerosol Science, 2017 - Elsevier
The major problem in understanding the therapeutically targeted drug delivery system in the
deeper airways of the human lung is the lack of adequate data of particle transport and …

Study on the transport and deposition of micron-sized particles with different densities in the coal mine environment in miners

Y Cheng, H Yu, Y Ye, Y Xie, J Zhao, S Xie - Fuel, 2024 - Elsevier
To address the health problems caused by the long-term intrusion of high-concentration dust
generated in coal mining operations into the human respiratory tract, this study …

Development of a formulation platform for a spray-dried, inhalable tuberculosis vaccine candidate

M Gomez, J McCollum, H Wang, M Ordoubadi… - International journal of …, 2021 - Elsevier
Protection against primarily respiratory infectious diseases, such as tuberculosis (TB), can
likely be enhanced through mucosal immunization induced by direct delivery of vaccines to …