Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …

Women who inherit a deleterious BRCA1 or BRCA2 mutation face substantially increased
risks of developing breast cancer, which is estimated at 70%. Although annual screening …

Background: Previous studies have reported a breast cancer (BC) risk reduction of
approximately 50% after risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 …

Data on survival of BRCA1/2‐associated primary breast cancer (PBC) patients who opt for
subsequent contralateral risk‐reducing mastectomy (CRRM) are scarce and inconsistent …

Purpose: The objective of this study was to estimate the risk of contralateral breast cancer in
BRCA1 and BRCA2 carriers; and measure the extent to which host, family history, and …

This meta-analysis investigates the oncological safety of breast-conserving therapy BCT in
BRCA-mutation carriers and the risk for contralateral breast cancer (CBC) compared with …

Purpose To determine whether adjuvant tamoxifen treatment for breast cancer (BC) is
associated with reduced contralateral breast cancer (CBC) risk for BRCA1 and/or BRCA2 …

Abstract The 1st International Consensus Conference for Breast Cancer in Young Women
(BCY1) took place in November 2012, in Dublin, Ireland organized by the European School …

Purpose To determine prospectively overall and age-specific estimates of contralateral
breast cancer (CBC) risk for young patients with breast cancer with or without BRCA1/2 …

BRCA1/2 mutation carriers are at a higher risk of breast cancer and of subsequent
contralateral breast cancer (CBC). This study aims to evaluate the evidence of the effect of …