Inflammatory bowel disease (IBD) is an immune-mediated inflammatory disease (IMID) of
the gastrointestinal tract and includes two subtypes: Crohn's disease and ulcerative colitis. It …

In this review, the role of innate and adaptive immunity in the pathogenesis of inflammatory
bowel diseases (IBD) is reported. In IBD, an altered innate immunity is often found, with …

Immunotherapy confers little to no benefit in the treatment of microsatellite stable (MSS)
metastatic colorectal cancer (mCRC). Mechanistic insights suggested that epidermal growth …

The gut microbiome is crucial for nutrient metabolism, immune regulation, and intestinal
homeostasis with changes in its composition linked to complex diseases like inflammatory …

Background The possibility of preventing inflammatory bowel disease (IBD) is becoming
more plausible due to advances in understanding preclinical disease and successful …

Objectives Digestive system diseases have evolved into a growing global burden without
sufficient therapeutic measures. Lactobacillus reuteri (L. reuteri) is considered as a new …

Introduction The intestinal barrier is a multi-faced structure lining the surface of the intestinal
mucosa of the GI tract. To exert its main functions as a physical and immunological defense …

11 Acknowledgement: We would like to thank the Helmsley Charitable Trust for their
generous 12 support of the PROMISE consortium (PRediction and PRevention through …

In patients with rheumatoid arthritis (RA), intestinal flora imbalance and butyrate metabolism
disorders precede clinical arthritis and are associated with the pathogenesis of RA. This …

The development of inflammatory bowel diseases (IBD) involves the breakdown of two
barriers: the epithelial barrier and the gut-vascular barrier (GVB). The destabilization of each …