Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit
information bidirectionally across the plasma membrane, and plays a critical role in …

The ex vivo generation of platelets from human-induced pluripotent cells (hiPSCs) is
expected to compensate donor-dependent transfusion systems. However, manufacturing the …

Achieving hemostasis following vascular injury requires the rapid accumulation of platelets
and fibrin. Here we used a combination of confocal intravital imaging, genetically …

The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs.
To address this issue, we developed a clinically applicable strategy for the derivation of …

Platelets in a thrombus interact with (anti) coagulation factors and support blood
coagulation. In the concept of cell‐based control of coagulation, three different roles of …

Intravital visualization of thrombopoiesis revealed that formation of proplatelets, which are
cytoplasmic protrusions in bone marrow megakaryocytes (MKs), is dominant in the steady …

Platelets are chief effector cells in hemostasis. In addition, they are multifaceted
inflammatory cells with functions that span the continuum from innate immune responses to …

For a long time, blood coagulation and innate immunity have been viewed as interrelated
responses. Recently, the presence of leukocytes at the sites of vessel injury has been …

Phosphatidylserine (PtdSer) exposure on the surface of activated platelets requires the
action of a phospholipid scramblase (s), and serves as a scaffold for the assembly of the …