Role of pyroptosis in inflammation and cancer

X Wei, F Xie, X Zhou, Y Wu, H Yan, T Liu… - Cellular & molecular …, 2022 - nature.com
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Immune response in COVID-19: what is next?

Q Li, Y Wang, Q Sun, J Knopf, M Herrmann… - Cell Death & …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more
than 2 years and it still impacts our daily lifestyle and quality in unprecedented ways. A …

The mechanism and consequences of SARS-CoV-2 spike-mediated fusion and syncytia formation

MM Rajah, A Bernier, J Buchrieser… - Journal of molecular …, 2022 - Elsevier
Syncytia are formed when individual cells fuse. SARS-CoV-2 induces syncytia when the
viral spike (S) protein on the surface of an infected cell interacts with receptors on …

The pathogenesis of coronavirus-19 disease

AC Borczuk, RK Yantiss - Journal of biomedical science, 2022 - Springer
Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal
agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably …

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

Omicron adopts a different strategy from Delta and other variants to adapt to host

X Du, H Tang, L Gao, Z Wu, F Meng, R Yan… - Signal transduction and …, 2022 - nature.com
With the ongoing of Corona Virus Disease 2019 (COVID-19) epidemic, new strains of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are continuously emerging. After …

Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation

J Cattin-Ortolá, LG Welch, SL Maslen, G Papa… - Nature …, 2021 - nature.com
The Spike (S) protein of SARS-CoV-2 binds ACE2 to direct fusion with host cells. S
comprises a large external domain, a transmembrane domain, and a short cytoplasmic tail …

The role of cell death in SARS-CoV-2 infection

C Yuan, Z Ma, J Xie, W Li, L Su, G Zhang, J Xu… - Signal transduction and …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), showing high
infectiousness, resulted in an ongoing pandemic termed coronavirus disease 2019 (COVID …

Long-term effects of SARS-CoV-2 infection on human brain and memory

Q Ding, HJ Zhao - Cell Death Discovery, 2023 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have caused
several waves of outbreaks. From the ancestral strain to Omicron variant, SARS-CoV-2 has …

Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection

Z Zhou, X Zhang, X Lei, X Xiao, T Jiao, R Ma… - … and Targeted Therapy, 2021 - nature.com
The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense RNA virus. How the …