About one-third of people with major depressive disorder (MDD) fail at least two antidepressant drug trials at 1 year. Together with clinical and experimental evidence …
EM Medina-Rodriguez, E Beurel - Neurobiology of disease, 2022 - Elsevier
The blood brain barrier (BBB) is a vital structure to protect the brain, tightly filtering the passage of nutrients and molecules from the blood to the brain. This is critical for …
W Bowe, NB Patel, AC Logan - Beneficial microbes, 2014 - wageningenacademic.com
Acne vulgaris has long been postulated to feature a gastrointestinal mechanism, dating back 80 years to dermatologists John H. Stokes and Donald M. Pillsbury. They hypothesised that …
AS Fouche, EFH Saunders, T Craig - Annals of Allergy, Asthma & …, 2014 - Elsevier
Background Hereditary angioedema (HAE) is characterized by edematous swelling attacks of the face, extremities, abdomen, genitalia, and upper airway. The potential for laryngeal …
AJ Sales, C Biojone, MS Terceti… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Epigenetic modifications are thought to play an important role in the neurobiology of depression. Antidepressant treatment induces histone acetylation …
F Qadri, M Bader - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Kinins are peptide mediators exerting their pro-inflammatory actions by the selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R …
C Albert-Weißenberger, AL Sirén… - Progress in neurobiology, 2013 - Elsevier
Acute ischemic stroke and traumatic brain injury are a major cause of mortality and morbidity. Due to the paucity of therapies, there is a pressing clinical demand for new …
This study was aimed to characterize the depression-like behaviour in the classical model of chronic inflammation induced by Complete Freund's Adjuvant (CFA). Male Swiss mice …
NR Kim, HY Kim, MH Kim, HM Kim, HJ Jeong - Life sciences, 2016 - Elsevier
Abstract Aims Sweetme Sweet Pumpkin™(SSP, baked Cucurbita moschata Duch.) has been used to treat patients with depression in Korea. However, the role of SSP in improving …