Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

The recent success of PD-1 and PD-L1 blockade in cancer therapy illustrates the important
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …

Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. Sepsis can induce acute kidney injury and multiple organ failures …

For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
response to infection that leads to uncontrolled inflammatory response followed by …

Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …

Sepsis is a systemic inflammatory response induced by an infection, leading to organ
dysfunction and mortality. Historically, sepsis-induced organ dysfunction and lethality were …

Sepsis—which is a severe life-threatening infection with organ dysfunction—initiates a
complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be …

Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …