The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …

Chemokines are a group of about 50 chemotactic cytokines crucial for the migration of
immune system cells and tumor cells, as well as for metastasis. One of the 20 chemokine …

Fifteen years have passed since the first description of interleukin (IL)-8/CXCL8 as a potent
neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types …

CXCR1 and CXCR2 chemokine receptors, mainly activated by interleukin 8 (IL-8 or CXCL8),
are expressed in a variety of cells including, leukocytes, fibroblasts, endothelial cells, and …

The presence of two CXCL8 receptor types combined with the inflammatory roles of PMN
has led to interest in whether each receptor type contributes to unique functions. PMN are …

Leukocyte trafficking into pulmonary tissue and airspaces is a critical component of the host
defense response. Activation and migration of polymorphonuclear leukocytes (PMNs) into …

Abstract Interleukin-8 (IL-8) activates neutrophils via the chemokine receptors CXCR1 and
CXCR2. However, the airways of individuals with cystic fibrosis are frequently colonized by …

Upon activation, neutrophils release DNA fibers decorated with antimicrobial proteins,
forming neutrophil extracellular traps (NETs),,. Although NETs are bactericidal and …

Lymphocyte chemotaxis is a complex process by which cells move within tissues and across
barriers such as vascular endothelium and is usually stimulated by chemokines such as …