Nonsteroidal antiinflammatory drugs (NSAID) are one of the most commonly used
medications worldwide to inhibiting COX activity for the treatment of pain and inflammation …

Nonsteroidal anti-inflammatory drugs represent the most commonly used medications for the
treatment of pain and inflammation, but numerous well-described side effects can limit their …

Cyclooxygenase-2 inhibitor blocks expression of mediators of renal injury in a model of
diabetes and hypertension. Background We previously reported that renal cortical …

Prostaglandins (PGs) generated by the enzyme cyclooxygenase (COX) have been
implicated in the pathological renal hemodynamics and structural alterations in diabetes …

Cyclooxygenase (COX)-2 is expressed in the heart in animal models of ischemic injury.
Recent studies have suggested that COX-2 products are involved in inflammatory cell …

Pharmacology of cyclooxygenase-2 inhibition in the kidney. Cyclooxygenase (COX) exists
as two unique isoforms (that is, COX-1 and COX-2) which are poorly understood with regard …

TS, SH, USA, ET MC., RS, AE-M., VJS, and MS have worked closely together for many
years. This overview is based on our earlier work and ongoing discussions within the group …

Chronic kidney disease is a leading cause of morbidity and mortality in the world. A better
understanding of disease mechanisms has been gained in recent years, but the current …

COX‐2/mPGES‐1/PGE2 cascade plays critical roles in modulating many physiological and
pathological actions in different organs. In the kidney, this cascade is of high importance in …

In a separate study, we identified PGE2 as a potent inhibitor of TGF-β1-induced epithelial-
mesenchymal transition (EMT) in cultured Madin-Darby canine kidney (MDCK) cells (Zhang …