The emerging role of ferroptosis in sepsis

Y Liu, S Tan, Y Wu, S Tan - DNA and cell biology, 2022 - liebertpub.com
Ferroptosis is a novel form of cell death characterized by the iron-dependent accumulation
of lipid peroxides and is different from other types of cell death. The mechanisms of …

Iron Chelation as a Potential Therapeutic Approach in Acute Lung Injury

X Zhang, J Zhou, BE Holbein, C Lehmann - Life, 2023 - mdpi.com
Acute lung injury (ALI) has been challenging health care systems since before the COVID-
19 pandemic due to its morbidity, mortality, and length of hospital stay. In view of the …

Iron overload and breast cancer: iron chelation as a potential therapeutic approach

S Islam, N Hoque, N Nasrin, M Hossain, F Rizwan… - Life, 2022 - mdpi.com
Breast cancer has historically been one of the leading causes of death for women
worldwide. As of 2020, breast cancer was reported to have overtaken lung cancer as the …

Dysregulated iron homeostasis as common disease etiology and promising therapeutic target

BE Holbein, C Lehmann - Antioxidants, 2023 - mdpi.com
Iron is irreplaceably required for animal and human cells as it provides the activity center for
a wide variety of essential enzymes needed for energy production, nucleic acid synthesis …

Hydroxypyridinone-Based Metal Chelators towards Ecotoxicity: Remediation and Biological Mechanisms

MA Santos, A Irto, P Buglyó, S Chaves - Molecules, 2022 - mdpi.com
Hydroxypyridinones (HPs) are recognized as excellent chemical tools for engineering a
diversity of metal chelating agents, with high affinity for hard metal ions, exhibiting a broad …

New polyazamacrocyclic 3-hydroxy-4-pyridinone based ligands for iron depletion antitumor activity

X Liu, X Dong, C He, X Zhang, G Xiang, X Ma - Bioorganic Chemistry, 2020 - Elsevier
Iron depletion is an efficient strategy for the development of anticancer agents. In an effort to
develop efficient chelators, two new 3-hydroxy-4-pyridinone based polyazamacrocycles 1e …

Iron withdrawal with DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, attenuates macrophage inflammatory responses

J Ghassemi-Rad, W Fernando… - Advanced …, 2022 - pmc.ncbi.nlm.nih.gov
Purpose: Iron is an essential trace element for the inflammatory response to infection. In this
study, we determined the effect of the recently developed iron-binding polymer DIBI on the …

DIBI, a novel polymeric iron chelator modulates IL-6 and IL-8 secretion from Cystic Fibrosis airway epithelial cells in response to endotoxin induction

M Aali, A Caldwell, A Li, B Holbein… - Journal of Cellular …, 2020 - content.iospress.com
Iron chelators have been utilized clinically to treat patients with iron overload conditions.
There is a growing body of evidence linking iron dysregulation and reactive oxygen species …

Auswirkungen von DIBI, einem neuartigen Eisenchelator, auf Leukozytenadhäsion, funktionelle Kapillardichte und Zytokinexpression in einem murinen Modell der …

G Hagn - 2020 - jlupub.ub.uni-giessen.de
HINTERGRUND: Die Interstitielle Cystitis (IC) beschreibt eine chronische Entzündung der
Blase, für die, aufgrund des ungeklärten Pathomechanismus, aktuell keine kausalen …

[引用][C] Role of Iron Chelation in Inflammation and Infection

M Aali - 2021