Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver
diseases, resulting in fatty liver, alcoholic hepatitis, fibrosis/cirrhosis, and hepatocellular …

Non-alcoholic fatty liver disease (NAFLD) constitutes a spectrum of disease states
characterized by hepatic steatosis and is closely associated to obesity and the metabolic …

Liver fibrosis is a common pathological feature of end stage liver failure, a severe life-
threatening disease worldwide. Nonalcoholic fatty liver disease (NAFLD), especially its more …

The connection between an altered gut microbiota and metabolic disorders such as obesity,
diabetes, and cardiovascular disease is well established,. Defects in preserving the integrity …

The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …

Abstract The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …

Summary Interleukin‐22 (IL‐22) has important functions in host defense at mucosal surfaces
as well as in tissue repair. It is unique as a cytokine that is produced by immune cells …

Importance of chronic fibroproliferative diseases (FDs) including pulmonary fibrosis, chronic
kidney diseases, inflammatory bowel disease, and cardiovascular or liver fibrosis is rapidly …

Janus protein tyrosine kinase (JAK) has the ability to activate signal transducer and activator
of transcription (STAT). STAT3 is a valued member of the JAK/STAT signaling pathway. In …

Background and Aims Interleukin‐22 has beneficial effects on inflammation and impaired
hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a …