Molecular regulation of autophagy machinery by mTOR‐dependent and‐independent pathways
MAA Al‐Bari, P Xu - Annals of the New York Academy of …, 2020 - Wiley Online Library
Macroautophagy is a lysosomal degradative pathway or recycling process that maintains
cellular homeostasis. This autophagy involves a series of sequential processing events …
cellular homeostasis. This autophagy involves a series of sequential processing events …
Auxin transporters—a biochemical view
From embryogenesis to fruit formation, almost every aspect of plant development and
differentiation is controlled by the cellular accumulation or depletion of auxin from cells and …
differentiation is controlled by the cellular accumulation or depletion of auxin from cells and …
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation
phosphoinositide-dependent kinase 1 (PDK1) is an essential serine/threonine protein
kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a …
kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a …
Targeting Smurf1 to block PDK1–Akt signaling in KRAS-mutated colorectal cancer
Z Peng, W Fang, B Wu, M He, S Li, J Wei… - Nature Chemical …, 2024 - nature.com
Abstract The phosphoinositide 3-kinase (PI3K)–Akt axis is one of the most frequently
activated pathways and is demonstrated as a therapeutic target in Kirsten rat sarcoma viral …
activated pathways and is demonstrated as a therapeutic target in Kirsten rat sarcoma viral …
[HTML][HTML] Pleckstrin Homology [PH] domain, structure, mechanism, and contribution to human disease
G Powis, EJ Meuillet, M Indarte, G Booher… - Biomedicine & …, 2023 - Elsevier
The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …
making it the 11th most common domain in the human proteome. 25% of family members …
[HTML][HTML] Comprehensive molecular characterization of polymorphous adenocarcinoma, cribriform subtype: Identifying novel fusions and fusion partners
E Hahn, B Xu, N Katabi, S Dogan, SM Smith… - Modern Pathology, 2023 - Elsevier
Polymorphous adenocarcinoma (PAC) is a common, usually low-grade salivary gland
carcinoma. While conventional PACs are most associated with PRKD1 p. E710D hotspot …
carcinoma. While conventional PACs are most associated with PRKD1 p. E710D hotspot …
Structural mechanism for Bruton's tyrosine kinase activation at the cell membrane
Bruton's tyrosine kinase (Btk) is critical for B cell proliferation and activation, and the
development of Btk inhibitors is a vigorously pursued strategy for the treatment of various B …
development of Btk inhibitors is a vigorously pursued strategy for the treatment of various B …
Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein
M Sacerdoti, LZF Gross, AM Riley, K Zehnder… - Science …, 2023 - science.org
The activation of at least 23 different mammalian kinases requires the phosphorylation of
their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide …
their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide …
Synthetic lethal approaches to target cancers with loss of PTEN function
Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in
inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol …
inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol …