[HTML][HTML] Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)
YY Qiu, J Zhang, FY Zeng, YZ Zhu - Pharmacological Research, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
[HTML][HTML] Integrated physiology and systems biology of PPARα
S Kersten - Molecular metabolism, 2014 - Elsevier
Abstract The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription
factor that plays a major role in metabolic regulation. This review addresses the functional …
factor that plays a major role in metabolic regulation. This review addresses the functional …
Molecular mechanisms of cancer development in obesity
MJ Khandekar, P Cohen, BM Spiegelman - Nature Reviews Cancer, 2011 - nature.com
The increasing incidence of obesity and its co-morbid conditions poses a great challenge to
global health. In addition to cardiovascular disease and diabetes, epidemiological data …
global health. In addition to cardiovascular disease and diabetes, epidemiological data …
The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors that are involved in regulating glucose and lipid homeostasis, inflammation …
factors that are involved in regulating glucose and lipid homeostasis, inflammation …
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
Y Horie, A Suzuki, E Kataoka, T Sasaki… - The Journal of …, 2004 - Am Soc Clin Investig
PTEN is a tumor suppressor gene mutated in many human cancers, and its expression is
reduced or absent in almost half of hepatoma patients. We used the Cre-loxP system to …
reduced or absent in almost half of hepatoma patients. We used the Cre-loxP system to …
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
JN Feige, L Gelman, L Michalik, B Desvergne… - Progress in lipid …, 2006 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) compose a family of three nuclear
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …
receptors which act as lipid sensors to modulate gene expression. As such, PPARs are …
Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities
CJ Omiecinski, JP Vanden Heuvel… - Toxicological …, 2011 - academic.oup.com
To commemorate the 50th anniversary of the Society of Toxicology, this special edition
article reviews the history and current scope of xenobiotic metabolism and transport, with …
article reviews the history and current scope of xenobiotic metabolism and transport, with …
The toxicology of perfluorooctanoate
GL Kennedy, JL Butenhoff, GW Olsen… - Critical reviews in …, 2004 - Taylor & Francis
ABSTRACT PFOA is a peroxisome proliferator (PPAR agonist) and exerts morphological
and biochemical effects characteristic of PPAR agonists. These effects include increased β …
and biochemical effects characteristic of PPAR agonists. These effects include increased β …
Liver hypertrophy: a review of adaptive (adverse and non-adverse) changes—conclusions from the 3rd International ESTP Expert Workshop
AP Hall, CR Elcombe, JR Foster… - Toxicologic …, 2012 - journals.sagepub.com
Preclinical toxicity studies have demonstrated that exposure of laboratory animals to liver
enzyme inducers during preclinical safety assessment results in a signature of toxicological …
enzyme inducers during preclinical safety assessment results in a signature of toxicological …
Activation of PPARα and PPARγ by environmental phthalate monoesters
CH Hurst, DJ Waxman - Toxicological sciences, 2003 - academic.oup.com
Phthalate esters are widely used as plasticizers in the manufacture of products made of
polyvinyl chloride. Mono-(2-ethylhexyl)-phthalate (MEHP) induces rodent …
polyvinyl chloride. Mono-(2-ethylhexyl)-phthalate (MEHP) induces rodent …