Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial
steps in the formation of ferroptosis include the accumulation of ferrous ions (Fe2+) and lipid …

Many solid tumors and hematologic malignancies lack expression of the enzyme
methylthioadenosine phosphorylase (MTAP), due either to deletion of the MTAP gene or to …

Background & Aims Hepatoblastoma (HB) is the most frequent childhood liver cancer.
Patients with aggressive tumors have limited therapeutic options; therefore, a better …

Gastric cancer (GC) typically carries a poor prognosis as it is often diagnosed at a late stage.
Altered metabolism has been found to impact cancer outcomes and affect patients' quality of …

In tumors, the rapid proliferation of cells and the imperfect blood supply system lead to
hypoxia, which can regulate the adaptation of tumor cells to the hypoxic environment …

Cancer cells have high demands for non-essential amino acids (NEAAs), which are
precursors for anabolic and antioxidant pathways that support cell survival and proliferation …

Background Protein arginine methyltransferase 5 (PRMT5), a type II PRMT, is highly
expressed in some tumors, but its role in hepatocellular carcinoma (HCC) is still unknown …

While the metabolic changes in cancer tissues were first observed by Warburg Otto almost a
century ago, altered metabolism has recently returned as a focus of cancer research. 5' …

NRAS-mutated melanoma lacks a specific line of treatment. Metabolic reprogramming is
considered a novel target to control cancer; however, NRAS-oncogene contribution to this …

Despite the promising targeted and immune-based interventions in melanoma treatment,
long-lasting responses are limited. Melanoma cells present an aberrant redox state that …