Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice
Fibrillar aggregates of the amyloid-β protein (Aβ) are the main component of the senile
plaques found in brains of patients with Alzheimer's disease (AD). Development of probes …
plaques found in brains of patients with Alzheimer's disease (AD). Development of probes …
Fluorescent diagnostic probes in neurodegenerative diseases
Neurodegenerative diseases are debilitating disorders that feature progressive and
selective loss of function or structure of anatomically or physiologically associated neuronal …
selective loss of function or structure of anatomically or physiologically associated neuronal …
Interrogating amyloid aggregates using fluorescent probes
Amyloids are a broad class of proteins and peptides that can misfold and assemble into long
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …
Photostable small-molecule NIR-II fluorescent scaffolds that cross the blood–brain barrier for noninvasive brain imaging
The second near-infrared (NIR-II, 1000–1700 nm) fluorescent probes have significant
advantages over visible or NIR-I (600–900 nm) imaging for both depth of penetration and …
advantages over visible or NIR-I (600–900 nm) imaging for both depth of penetration and …
Evaluation of peptide/protein self-assembly and aggregation by spectroscopic methods
MF Pignataro, MG Herrera, VI Dodero - Molecules, 2020 - mdpi.com
The self-assembly of proteins is an essential process for a variety of cellular functions
including cell respiration, mobility and division. On the other hand, protein or peptide …
including cell respiration, mobility and division. On the other hand, protein or peptide …
Near‐Infrared Aggregation‐Induced Emission Luminogens for In Vivo Theranostics of Alzheimer's Disease
T Zhang, X Chen, C Yuan, X Pang… - Angewandte Chemie …, 2023 - Wiley Online Library
Optimized theranostic strategies for Alzheimer's disease (AD) remain almost absent from
bench to clinic. Current probes and drugs attempting to prevent β‐amyloid (Aβ) fibrosis …
bench to clinic. Current probes and drugs attempting to prevent β‐amyloid (Aβ) fibrosis …
Advanced techniques for detecting protein misfolding and aggregation in cellular environments
Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …
[HTML][HTML] Boron chemicals in drug discovery and development: Synthesis and medicinal perspective
BC Das, NK Nandwana, S Das, V Nandwana… - Molecules, 2022 - mdpi.com
A standard goal of medicinal chemists has been to discover efficient and potent drug
candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive …
candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive …
Near-infrared fluorescent probes as imaging and theranostic modalities for amyloid-beta and tau aggregates in Alzheimer's disease
A person suspected of having Alzheimer's disease (AD) is clinically diagnosed for the
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …
Use of curcumin, a natural polyphenol for targeting molecular pathways in treating age-related neurodegenerative diseases
P Maiti, GL Dunbar - International journal of molecular sciences, 2018 - mdpi.com
Progressive accumulation of misfolded amyloid proteins in intracellular and extracellular
spaces is one of the principal reasons for synaptic damage and impairment of neuronal …
spaces is one of the principal reasons for synaptic damage and impairment of neuronal …