Lower back pain (LBP) occurs in 80% of adults in their lifetime; resulting in LBP being one of
the biggest causes of disability worldwide. Chronic LBP has been linked to the degeneration …

Chronic low back pain is the number one cause of years lived with disability. In about 40% of
patients, chronic lower back pain is related to intervertebral disc (IVD) degeneration. The …

Introduction: As many as 80% of the adult population experience back pain at some point in
their lifetimes. Previous studies have indicated a link between back pain and intervertebral …

In recent decades the application of bioreactors has revolutionized the concept of culturing
tissues and organs that require mechanical loading. In intervertebral disc (IVD) research …

Intervertebral disc degeneration (IDD) is a prevalent musculoskeletal degenerative disorder
worldwide, and~ 40% of chronic low back pain cases are associated with IDD. Although the …

Background Lineage‐tracing experiments have established that the central region of the
mature intervertebral disc, the nucleus pulposus (NP), develops from the embryonic …

During intervertebral disc (IVD) maturation, the main cell type shifts from notochordal cells
(NCs) to chondrocytelike cells (CLCs). NCs secrete factors with regenerative potential …

The socioeconomic burden of chronic back pain related to intervertebral disc (IVD) disease
is high and current treatments are only symptomatic. Minimally invasive strategies that …

Lower back pain from degenerative disc disease represents a global health burden, and
presents a prominent opportunity for regenerative therapeutics. While current regenerative …

The intervertebral disc (IVD) is the largest avascular organ of the human body and plays a
fundamental role in providing the spine with its unique structural and biomechanical …