Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Despite the discovery of heterotrimeric αβγ G proteins∼ 25 years ago, their selective
perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report …

Solute carrier spinster homolog 2 (SPNS2), one of only four known major facilitator
superfamily (MFS) lysolipid transporters in humans, exports sphingosine-1-phosphate (S1P) …

The peripheral somatosensory system bestows mammals with a diverse repertoire of
sensory modalities: gentle touch, mechanical pain, itch, thermosensation, and …

Background Triple negative breast cancer (TNBC) is a particularly aggressive and difficult-to-
treat subtype of breast cancer that requires the development of novel therapeutic strategies …

Alcohol use disorder (AUD) and chronic pain are enduring and devastating conditions that
share an intersecting epidemiology and neurobiology. Chronic alcohol use itself can …

Opioid craving and relapse vulnerability is associated with severe and persistent sleep and
circadian rhythm disruptions. Understanding the neurobiological underpinnings of circadian …

Alcohol use disorder (AUD) is a common and chronic disorder with substantial effects on
personal and public health. The underlying pathophysiology is poorly understood but strong …

The heat-and capsaicin-sensitive transient receptor potential vanilloid 1 ion channel
(TRPV1) is regulated by plasma membrane phosphoinositides. The effects of these lipids on …