Although it is well known that proteins are only marginally stable in their folded states, it is
often less well appreciated that most proteins are inherently aggregation-prone in their …

Highlights•Proteins aggregate in a variety of ways, most of which are unwanted in drug
products.•Possible impacts on product quality include deliverability and immunogenicity.• …

Buffers comprise an integral component of protein formulations. Not only do they function to
regulate shifts in pH, they also can stabilize proteins by a variety of mechanisms. The ability …

Renewable, green and cheap biomass could meet the urgent need of cost-effective
graphene quantum dots (GQDs) if microstructure and quality can be precisely controlled …

At low protein concentrations (c 2), non-native protein aggregation rates are known to be
sensitive to changes in conformational stability and “weak” or “colloidal” protein–protein …

The effects of high pressure and low temperature on the stability of two different monoclonal
antibodies (MAbs) were examined in this work. Fluorescence and small-angle neutron …

Aggregation of mAbs is a crucial concern with respect to their safety and efficacy. Among the
various properties of protein aggregates, it is emerging that their size can potentially impact …

Citrate is a common buffer for slightly acidic pH ranges of protein formulations. In the
presence of iron, citrate buffer undergoes photo-degradation induced by near UV and visible …

Self-association of monoclonal antibodies (mAbs) at high concentrations can result in
developability challenges such as poor solubility, aggregation, opalescence and high …

Prediction of lyophilized product shelf-life using accelerated stability data requires
understanding the temperature dependence of the degradation rate. Despite the abundance …