Overcoming ocular drug delivery barriers through the use of physical forces

D Huang, YS Chen, ID Rupenthal - Advanced drug delivery reviews, 2018 - Elsevier
Overcoming the physiological barriers in the eye remains a key obstacle in the field of ocular
drug delivery. While ocular barriers naturally have a protective function, they also limit drug …

Making waves: how ultrasound-targeted drug delivery is changing pharmaceutical approaches

LJ Delaney, S Isguven, JR Eisenbrey, NJ Hickok… - Materials …, 2022 - pubs.rsc.org
Administration of drugs through oral and intravenous routes is a mainstay of modern
medicine, but this approach suffers from limitations associated with off-target side effects and …

Dendrimers in corneal drug delivery: recent developments and translational opportunities

A Dhull, C Yu, AH Wilmoth, M Chen, A Sharma, S Yiu - Pharmaceutics, 2023 - mdpi.com
Dendrimers are biocompatible organic nanomaterials with unique physicochemical
properties, making them the focus of recent research in drug delivery. The cornea of the …

Novel insights into gene therapy in the cornea

RR Mohan, LM Martin, NR Sinha - Experimental eye research, 2021 - Elsevier
Corneal disease remains a leading cause of impaired vision world-wide, and advancements
in gene therapy continue to develop with promising success to prevent, treat and cure …

How are we improving the delivery to back of the eye? Advances and challenges of novel therapeutic approaches

V Agrahari, V Agrahari, A Mandal, D Pal… - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: Drug delivery to the back of the eye requires strategic approaches that
guarantee the long-term therapeutic effect with patient compliance. Current treatments for …

Current advances in nano-based and polymeric stimuli-responsive drug delivery targeting the ocular microenvironment: a review and envisaged future perspectives

SBK Dludla, LT Mashabela, B Ng'andwe, PA Makoni… - Polymers, 2022 - mdpi.com
Optimal vision remains one of the most essential elements of the sensory system
continuously threatened by many ocular pathologies. Various pharmacological agents …

Therapeutic systems and technologies: State-of-the-art applications, opportunities, and challenges

M Almekkawy, J Chen, MD Ellis… - IEEE reviews in …, 2019 - ieeexplore.ieee.org
In this review, we present current state-of-the-art developments and challenges in the areas
of thermal therapy, ultrasound tomography, image-guided therapies, ocular drug delivery …

Ultrasound-mediated ocular delivery of therapeutic agents: a review

M Lafond, F Aptel, JL Mestas… - Expert Opinion on Drug …, 2017 - Taylor & Francis
Introduction: Due to numerous anatomical and physiological barriers, ocular drug delivery
remains a major limitation in the treatment of diseases such as glaucoma, macular …

Thermal safety of ultrasound‐enhanced ocular drug delivery: a modeling study

M Nabili, C Geist, V Zderic - Medical physics, 2015 - Wiley Online Library
Purpose: Delivery of sufficient amounts of therapeutic drugs into the eye for treatment of
various ocular diseases is often a challenging task. Ultrasound was shown to be effective in …

Enhanced topical corticosteroids delivery to the eye: A trade-off in strategy choice

L Shen, G Fang, B Tang, Q Zhu - Journal of Controlled Release, 2021 - Elsevier
Topical corticosteroids are the primary treatment of ocular inflammation caused by surgery,
injury, or other conditions. Drug pre-corneal residence time, drug water solubility, and drug …