Pathogenic role of fibrinogen in the neuropathology of multiple sclerosis: a tale of sorrows and fears

M Alruwaili, HM Al-Kuraishy, A Alexiou… - Neurochemical …, 2023 - Springer
Multiple sclerosis (MS) is an autoimmune demyelinating neurodegenerative disease of the
central nervous system (CNS) due to injury of the myelin sheath by immune cells. The …

[HTML][HTML] Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease

MT Jeon, KS Kim, ES Kim, S Lee, J Kim, HS Hoe… - Ageing research …, 2021 - Elsevier
The responses of central nervous system (CNS) cells such as neurons and glia in
neurodegenerative diseases (NDs) suggest that regulation of neuronal and glial functions …

Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model

Z Zhou, C Liu, S Xu, J Wang, F Guo, S Duan… - Basic Research in …, 2022 - Springer
The stellate ganglia play an important role in cardiac remodeling after myocardial infarction
(MI). This study aimed to investigate whether adiponectin (APN), an adipokine mainly …

Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms

MS Ivraghi, MY Zamanian, R Gupta… - CNS Neuroscience …, 2024 - Wiley Online Library
Abstract Background Gemfibrozil (Gem) is a drug that has been shown to activate PPAR‐α,
a nuclear receptor that plays a key role in regulating lipid metabolism. Gem is used to lower …

PLASTAMINATION: Outcomes on the Central Nervous System and Reproduction

A Santoro, M Marino, LN Vandenberg… - Current …, 2024 - benthamdirect.com
Background: Environmental exposures to non-biodegradable and biodegradable plastics
are unavoidable. Microplastics (MPs) and nanoplastics (NPs) from the manufacturing of …

The immune system's role in the consequences of mild traumatic brain injury (concussion)

LN Verboon, HC Patel, AD Greenhalgh - Frontiers in immunology, 2021 - frontiersin.org
Mild traumatic brain injury (mild TBI), often referred to as concussion, is the most common
form of TBI and affects millions of people each year. A history of mild TBI increases the risk of …

Extensive characterization of the composition and functional activities of five preparations of human platelet lysates for dedicated clinical uses

L Delila, YW Wu, O Nebie, R Widyaningrum, ML Chou… - Platelets, 2021 - Taylor & Francis
Human platelet lysates (HPLs), rich in various growth factors and cell growth-promoting
molecules, encompass a new range of blood products that are being used for regenerative …

Fibrinogen, fibrinogen-like 1 and fibrinogen-like 2 proteins, and their effects

NH Sulimai, J Brown, D Lominadze - Biomedicines, 2022 - mdpi.com
Fibrinogen (Fg) and its derivatives play a considerable role in many diseases. For example,
increased levels of Fg have been found in many inflammatory diseases, such as Alzheimer's …

Vascular effects on cerebrovascular permeability and neurodegeneration

N Sulimai, J Brown, D Lominadze - Biomolecules, 2023 - mdpi.com
Neurons and glial cells in the brain are protected by the blood brain barrier (BBB). The local
regulation of blood flow is determined by neurons and signal conducting cells called …

Targeting the cerebrovascular system: next-generation biomarkers and treatment for mild traumatic brain injury

TL Baker, DV Agoston, RD Brady, B Major… - The …, 2022 - journals.sagepub.com
The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as
concussions, are significant unmet medical issues. The kinetic forces that occur in mTBI …