Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease

V Poli, I Zanoni - Trends in microbiology, 2023 - cell.com
Neutrophil extracellular traps (NETs) evolved to protect the host against microbial infections
and are formed by a web-like structure of DNA that is decorated with antimicrobial effectors …

Aetiology and pathogenesis of hidradenitis suppurativa

K Wolk, O Join‐Lambert, R Sabat - British Journal of …, 2020 - academic.oup.com
Hidradenitis suppurativa (HS) is a chronic inflammatory disorder. Patients develop inflamed
nodules and abscesses and, at later stages of disease, epithelialized tunnels and scars in …

What causes hidradenitis suppurativa?—15 years after

CC Zouboulis, F Benhadou, AS Byrd… - Experimental …, 2020 - Wiley Online Library
The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis
published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International …

[HTML][HTML] Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis

JE Gudjonsson, LC Tsoi, F Ma, AC Billi… - JCI insight, 2020 - ncbi.nlm.nih.gov
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease
characterized by chronic abscess formation and development of multiple draining sinus …

[HTML][HTML] Immunopathogenesis of hidradenitis suppurativa and response to anti–TNF-α therapy

MM Lowe, HB Naik, S Clancy, M Pauli, KM Smith, Y Bi… - JCI insight, 2020 - ncbi.nlm.nih.gov
Hidradenitis suppurativa (HS) is a highly prevalent, morbid inflammatory skin disease with
limited treatment options. The major cell types and inflammatory pathways in skin of patients …

[HTML][HTML] Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis

C Carmona-Rivera, PM Carlucci, RR Goel, E James… - JCI insight, 2020 - ncbi.nlm.nih.gov
Rheumatoid arthritis (RA) is characterized by synovial joint inflammation, cartilage damage,
and dysregulation of the adaptive immune system. While neutrophil extracellular traps …

Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa

K Navrazhina, JW Frew, P Gilleaudeau… - Journal of Allergy and …, 2021 - Elsevier
Background Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic,
painful, and burdensome inflammatory disease manifesting in nodules and abscesses, with …

Identification of biomarkers and critical evaluation of biomarker validation in hidradenitis suppurativa: a systematic review

S Der Sarkissian, S Hessam, JS Kirby… - JAMA …, 2022 - jamanetwork.com
Importance The identification and validation of biomarkers in hidradenitis suppurativa (HS)
has potential to improve the understanding and management of this chronic, burdensome …

IL-17 in inflammatory skin diseases psoriasis and hidradenitis suppurativa

JM Fletcher, B Moran, A Petrasca… - Clinical & Experimental …, 2020 - academic.oup.com
The skin is one of the most important organs in the body, providing integrity and acting as a
barrier to exclude microbes, allergens and chemicals. However, chronic skin inflammation …

Insights into hidradenitis suppurativa

KR van Straalen, EP Prens, JE Gudjonsson - Journal of Allergy and Clinical …, 2022 - Elsevier
Hidradenitis suppurativa (HS) is a chronic, debilitating, inflammatory skin disorder with a
prevalence of around 1% and a profound impact on patients' quality of life. Characteristic …