Understanding the drivers of MHC restriction of T cell receptors
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
Immunoglobulin germline gene variation and its impact on human disease
Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …
Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening
CD4+ T cells are critical to fighting pathogens, but a comprehensive analysis of human T-
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …
Identifying specificity groups in the T cell receptor repertoire
T cell receptor (TCR) sequences are very diverse, with many more possible sequence
combinations than T cells in any one individual,,,. Here we define the minimal requirements …
combinations than T cells in any one individual,,,. Here we define the minimal requirements …
Observed antibody space: a resource for data mining next-generation sequencing of antibody repertoires
Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …
sequence diversity and binding versatility have made Abs the primary class of …
Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires
The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …
Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity
MM Corcoran, GE Phad, NV Bernat… - Nature …, 2016 - nature.com
Comprehensive knowledge of immunoglobulin genetics is required to advance our
understanding of B cell biology. Validated immunoglobulin variable (V) gene databases are …
understanding of B cell biology. Validated immunoglobulin variable (V) gene databases are …
iReceptor: a platform for querying and analyzing antibody/B‐cell and T‐cell receptor repertoire data across federated repositories
BD Corrie, N Marthandan, B Zimonja… - Immunological …, 2018 - Wiley Online Library
Next‐generation sequencing allows the characterization of the adaptive immune receptor
repertoire (AIRR) in exquisite detail. These large‐scale AIRR‐seq data sets have rapidly …
repertoire (AIRR) in exquisite detail. These large‐scale AIRR‐seq data sets have rapidly …
Systems analysis reveals high genetic and antigen-driven predetermination of antibody repertoires throughout B cell development
Antibody repertoire diversity and plasticity is crucial for broad protective immunity.
Repertoires change in size and diversity across multiple B cell developmental stages and in …
Repertoires change in size and diversity across multiple B cell developmental stages and in …
Impaired B‐cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies
E Meffre, KC O'Connor - Immunological reviews, 2019 - Wiley Online Library
A role for B cells in autoimmune diseases is now clearly established both in mouse models
and humans by successful treatment of multiple sclerosis and rheumatoid arthritis with anti …
and humans by successful treatment of multiple sclerosis and rheumatoid arthritis with anti …