The cytosine analogues 5‐azacytosine (azacytidine) and 2′‐deoxy‐5‐azacytidine
(decitabine) are the currently most advanced drugs for epigenetic cancer therapies. These …

Nucleoside transporters mediate cellular uptake of physiologic nucleosides for nucleic acid
synthesis in the salvage pathways in many cell types. These transporters also play an …

Nucleoside analogs are important components of treatment regimens for various
malignancies. Nucleoside-specific membrane transporters mediate plasma membrane …

Purpose: Concentrative nucleoside transporter (CNT) 1, CNT3, equilibrative nucleoside
transporter (ENT) 1, and, to a lesser extent, ENT2, appear to be the transporters responsible …

Concentrative nucleoside transporters (CNT; SLC28) and equilibrative nucleoside
transporters (ENT; SLC29) mediate the uptake of natural nucleosides and a variety of …

Nucleoside and nucleobase analogs are currently used in the treatment of solid tumors,
lymphoproliferative diseases, viral infections such as hepatitis and AIDS, and some …

The purine nucleoside analogs (PNA) form an important group of cytotoxic drugs active in
the treatment of neoplastic and autoimmune diseases. Three of them, fludarabine (FA) …

Acadesine, 5-aminoimidazole-4-carboxamide (AICA) riboside, induced apoptosis in B-cell
chronic lymphocytic leukemia (B-CLL) cells in all samples tested (n= 70). The half-maximal …

Adenosine compartmentalization has a profound impact on immune cell function by
regulating adenosine localization and, therefore, extracellular signaling capabilities, which …

Some nucleoside analogues currently used as antiretroviral agents might promote
mutagenesis besides their putative ability to interfere with endogenous nucleotide …