Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy
Extensive growth of cancer in humans is a major cause of death. Numerous studies are
being conducted to improve the early diagnosis, prevention, and treatment of cancer. Recent …
being conducted to improve the early diagnosis, prevention, and treatment of cancer. Recent …
Gamma delta T cell therapy for cancer: it is good to be local
CD Pauza, ML Liou, T Lahusen, L Xiao… - Frontiers in …, 2018 - frontiersin.org
Human gamma delta T cells have extraordinary properties including the capacity for tumor
cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and …
cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and …
Exosomes derived from human primary and metastatic colorectal cancer cells contribute to functional heterogeneity of activated fibroblasts by reprogramming their …
Cancer‐associated fibroblasts (CAFs) are a heterogeneous population of activated
fibroblasts that constitute a dominant cellular component of the tumor microenvironment …
fibroblasts that constitute a dominant cellular component of the tumor microenvironment …
Novel prospects of statins as therapeutic agents in cancer
Statins are well known competitive inhibitors of hydroxymethylglutaryl-CoA reductase
enzyme (HMG-CoA reductase), thus traditionally used as cholesterol-lowering agents. In …
enzyme (HMG-CoA reductase), thus traditionally used as cholesterol-lowering agents. In …
Farnesyl pyrophosphate synthase: a key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development
As isoprenoid biosynthetic pathway has gained importance since last few years, key
enzymes of this pathway have been characterized and their functional roles in the cell …
enzymes of this pathway have been characterized and their functional roles in the cell …
[HTML][HTML] Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells
The mevalonate pathway provides metabolites for post-translational modifications such as
farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently …
farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently …
The potential to treat lung cancer via inhalation of repurposed drugs
Lung cancer is a highly invasive and prevalent disease with ineffective first-line treatment
and remains the leading cause of cancer death in men and women. Despite the …
and remains the leading cause of cancer death in men and women. Despite the …
Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers
DD Waller, J Park, YS Tsantrizos - Critical reviews in biochemistry …, 2019 - Taylor & Francis
Dysregulation of isoprenoid biosynthesis is implicated in numerous biochemical disorders
that play a role in the onset and/or progression of age-related diseases, such as …
that play a role in the onset and/or progression of age-related diseases, such as …
Phosphonate and bisphosphonate inhibitors of farnesyl pyrophosphate synthases: A structure-guided perspective
Phosphonates and bisphosphonates have proven their pharmacological utility as inhibitors
of enzymes that metabolize phosphate and pyrophosphate substrates. The blockbuster …
of enzymes that metabolize phosphate and pyrophosphate substrates. The blockbuster …
Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling
Background Radiation therapy (RT) has a suboptimal effect in patients with pancreatic
ductal adenocarcinoma (PDAC) due to intrinsic and acquired radioresistance (RR) …
ductal adenocarcinoma (PDAC) due to intrinsic and acquired radioresistance (RR) …