Ex-vivo Kidney Machine Perfusion: Therapeutic Potential

R Zulpaite, P Miknevicius, B Leber, K Strupas… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

Treatment of transplant kidneys during machine perfusion

SA Hosgood, M Hoff, ML Nicholson - Transplant International, 2021 - Wiley Online Library
The increasing use of donation after circulatory death (DCD) and extended criteria donor
(ECD) organs has raised awareness of the need to improve the quality of kidneys for …

Machine perfusion of donor organs for transplantation

R Tatum, TJ O'Malley, AS Bodzin… - Artificial …, 2021 - Wiley Online Library
The ever‐widening gap between organ supply and demand has resulted in an organ
shortage crisis that affects patients all over the world. For decades, static cold storage (SCS) …

Renal delivery of pharmacologic agents during machine perfusion to prevent ischaemia-reperfusion injury: from murine model to clinical trials

R Franzin, A Stasi, M Fiorentino, S Simone… - Frontiers in …, 2021 - frontiersin.org
Donor organ shortage still remains a serious obstacle for the access of wait-list patients to
kidney transplantation, the best treatment for End-Stage Kidney Disease (ESKD). To expand …

A potent truncated form of human soluble CR1 is protective in a mouse model of renal ischemia–reperfusion injury

AK Bongoni, IB Vikstrom, JL McRae, EJ Salvaris… - Scientific Reports, 2021 - nature.com
The complement system is a potent mediator of ischemia–reperfusion injury (IRI), which
detrimentally affects the function and survival of transplanted kidneys. Human complement …

Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery

IF Delaura, Q Gao, IJ Anwar, N Abraham… - Frontiers in …, 2022 - frontiersin.org
Organ shortages and an expanding waitlist have led to increased utilization of marginal
organs. All donor organs are subject to varying degrees of IRI during the transplant process …

How to Best Protect Kidneys for Transplantation—Mechanistic Target

S Akalay, SA Hosgood - Journal of Clinical Medicine, 2023 - mdpi.com
The increasing number of patients on the kidney transplant waiting list underlines the need
to expand the donor pool and improve kidney graft utilization. By protecting kidney grafts …

Local complement synthesis—A process with near and far consequences for ischemia reperfusion injury and transplantation

CL Nauser, SH Sacks - Immunological Reviews, 2023 - Wiley Online Library
The model of the solid organ as a target for circulating complement deposited at the site of
injury, for many years concealed the broader influence of complement in organ …

The role of ex-situ perfusion for thoracic organs

MJ Roesel, B Wiegmann, F Ius… - Current Opinion in …, 2022 - journals.lww.com
The role of ex-situ perfusion for thoracic organs : Current Opinion in Organ Transplantation The
role of ex-situ perfusion for thoracic organs : Current Opinion in Organ Transplantation Log in or …

Repurposing of metformin and colchicine reveals differential modulation of acute and chronic kidney injury

M El-Rashid, D Nguyen-Ngo, N Minhas, DN Meijles… - Scientific Reports, 2020 - nature.com
Acute kidney injury (AKI) is a major health problem affecting millions of patients globally.
There is no effective treatment for AKI and new therapies are urgently needed. Novel drug …