Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Histone variants provide versatility in the basic unit of chromatin, helping to define dynamic
landscapes and cell fates. Maintaining genome integrity is paramount for the cell, and it is …

Rapid climate change is placing many marine species at risk of local extinction. Recent
studies show that epigenetic mechanisms (eg DNA methylation, histone modifications) can …

Chromatin structure, transcription, DNA replication, and repair are regulated via locus-
specific incorporation of histone variants and posttranslational modifications that guide …

Histone variant H3. 3 plays novel roles in development as compared to canonical H3
proteins and is the most commonly mutated histone protein of any kind in human disease …

The lack of a consensus DNA sequence defining replication origins in mammals has led
researchers to consider chromatin as a means to specify these regions. However, to date …

The histone H3 variant H3. 3, encoded by two genes H3-3A and H3-3B, can replace
canonical isoforms H3. 1 and H3. 2. H3. 3 is important in chromatin compaction, early …

Epigenetic inheritance refers to the transmission of phenotypes across generations without
affecting the genomic DNA sequence. Even though it has been documented in many …

Histone variant H3. 3 is incorporated into chromatin throughout the cell cycle and even in
non-cycling cells. This histone variant marks actively transcribed chromatin regions with high …

Obesity impairs oocyte quality, fertility, pregnancy maintenance, and is associated with
offspring birth defects. The model ovotoxicant, 7, 12-dimethylbenz [a] anthracene (DMBA) …