Vitamin A is essential for the formation and maintenance of many body tissues. It is also
important for embryonic growth and development and can act as a teratogen at critical …

Introduction: Retinoic acid X receptors play key roles in tumor cell proliferation,
differentiation, apoptosis and angiogenesis via transcriptional regulation. Bexarotene is a …

Infiltration of specialized immune cells regulates the growth and survival of neoplasia. Here,
in a survey of public whole genome expression datasets we found that the gene for …

The identification of novel drug targets for the treatment of ischemic stroke is currently an
urgent challenge. Recent experimental findings have highlighted the neuroprotective …

Rosiglitazone (ROSI), a member of thiazolidinediones (TZDs) which act as high-affinity
agonists of the nuclear receptor peroxisome-proliferator-activated receptor-γ (PPARγ), is …

Connectivity mapping is a recently developed technique for discovering the underlying
connections between different biological states based on gene-expression similarities. The …

Cancer is currently the second leading cause of death in the United States. There is
increasing evidence that the tumor microenvironment (TME) is pivotal for tumorigenesis and …

Undifferentiated (anaplastic) thyroid cancer (ATC) is one of the most aggressive human
malignancies and no effective therapy is currently available. We show here that PPARγ …

Skin homeostasis is maintained, in part, through regulation of gene expression orchestrated
by type II nuclear hormone receptors in a cell and context specific manner. This group of …

Thiazolidinediones are known to have antidiabetic activity, but new activities are being
discovered every year; among these, their anticancer activity has received the most …