Applications of palladium-catalyzed C–N cross-coupling reactions

P Ruiz-Castillo, SL Buchwald - Chemical reviews, 2016 - ACS Publications
Pd-catalyzed cross-coupling reactions that form C–N bonds have become useful methods to
synthesize anilines and aniline derivatives, an important class of compounds throughout …

Chromone: a valid scaffold in medicinal chemistry

A Gaspar, MJ Matos, J Garrido, E Uriarte… - Chemical …, 2014 - ACS Publications
Chromones are a group of naturally occurring compounds that are ubiquitous in nature,
especially in plants. The word chromone is derived from the Greek word chroma, meaning …

Chromones as a privileged scaffold in drug discovery: A review

RS Keri, S Budagumpi, RK Pai… - European Journal of …, 2014 - Elsevier
The chromone and its derivatives are the most important heterocyclic compounds, which is a
common and integral feature of a variety of natural products and medicinal agents. These …

Pd-catalyzed cross-couplings: On the importance of the catalyst quantity descriptors, mol% and ppm

CS Horbaczewskyj, IJS Fairlamb - Organic Process Research & …, 2022 - ACS Publications
This Review examines parts per million (ppm) palladium concentrations in catalytic cross-
coupling reactions and their relationship with mole percentage (mol%). Most studies in …

Chromone, a privileged scaffold in drug discovery: Developments in the synthesis and bioactivity

AT Benny, SD Arikkatt, CG Vazhappilly… - Mini Reviews in …, 2022 - ingentaconnect.com
Chromones are the class of secondary metabolites that broadly occur in the plant kingdom
in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged …

A Bulky and Electron-Rich N-Heterocyclic Carbene–Palladium Complex (SIPr)Ph2Pd(cin)Cl: Highly Efficient and Versatile for the Buchwald–Hartwig Amination of …

JS Ouyang, S Liu, B Pan, Y Zhang, H Liang… - ACS …, 2021 - ACS Publications
A bulky and electron-rich N-heterocyclic carbene–palladium complex (SIPr) Ph2Pd (cin) Cl
was synthesized and characterized. It was found to be highly efficient and versatile for the …

Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds

R Emadi, AB Nekoo, F Molaverdi, Z Khorsandi… - RSC …, 2023 - pubs.rsc.org
C–N cross-coupling bond formation reactions have become valuable approaches to
synthesizing anilines and their derivatives, known as important chemical compounds …

Chromone scaffolds in the treatment of Alzheimer's and Parkinson's disease: an overview

K Sharma - ChemistrySelect, 2022 - Wiley Online Library
Neurodegenerative disorders such as Alzheimer's (AD) and Parkinson's disease (PD)
usually starts gradually and progressively worsens, and are recognized as one of the …

Synthesis of 3-tetrazolylmethyl-4H-chromen-4-ones via Ugi-azide and biological evaluation against Entamoeba histolytica, Giardia lamblia and Trichomona vaginalis

PA Cano, A Islas-Jácome, J González-Marrero… - Bioorganic & Medicinal …, 2014 - Elsevier
The synthesis of novel 3-tetrazolylmethyl-4H-chromen-4-ones via an Ugi-azide
multicomponent reaction and their biological evaluation against Entamoeba histolytica …

Current insights of inhibitors of p38 mitogen-activated protein kinase in inflammation

A Awasthi, MB Raju, MA Rahman - Medicinal Chemistry, 2021 - ingentaconnect.com
Background: The inflammatory process is one of the mechanisms by which our body
upholds us from pathogens such as parasites, bacteria, viruses, and other harmful …