Significance: Excessive scarring is major clinical and financial burden in the United States.
Improved therapies are necessary to reduce scarring, especially in patients affected by …

Fibrotic scars deposited during skin wound healing can cause disfiguration and loss of
dermal function. Scar differentiation involves inputs from multiple cell types in a predictable …

Oxygen plays a key role in wound healing, and hypoxia is a major cause of wound healing
impairment; therefore, treatments to improve hemodynamics and increase wound …

Wound repair involves the sequential interaction of various cell types, extracellular matrix
molecules, and soluble mediators. During the past 10 years, much new information on …

Cutaneous wounds inevitably heal with scars, which can be disfiguring and compromise
function. In general, the greater the insult, the worse the scarring, although genetic make up …

Hypertrophic scarring after burns is an unsolved problem and remains as devastating today
as it was in the 40s and it may be that the main reason for this is the lack of an accepted …

Gene therapy was traditionally considered a treatment modality for patients with congenital
defects of key metabolic functions or late-stage malignancies. The realization that gene …

BACKGROUND Hypertrophic scarring is the major significant negative outcome after
survival from of a thermal injury. Hypertrophic scars are hard, raised, red, itchy, tender, and …

Objective: It has been proved that platelet-rich plasma (PRP) can promote wound healing. In
this way, PRP can be advantageous in periodontal plastic surgeries, free gingival graft …

Scar is the default tissue repair used by the body in response to most injuries–a response
that occurs in wounds ranging in seriousness from minor skin cuts to complete severance of …