RNA structural dynamics as captured by molecular simulations: a comprehensive overview
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
pluripotent chemical species in molecular biology, and its functions are intimately linked to …
Characterizing micro-to-millisecond chemical exchange in nucleic acids using off-resonance R1ρ relaxation dispersion
This review describes off-resonance R 1ρ relaxation dispersion NMR methods for
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …
2′-O-Methylation can increase the abundance and lifetime of alternative RNA conformational states
O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays
important biological roles through mechanisms that are not entirely understood. There is …
important biological roles through mechanisms that are not entirely understood. There is …
Kinetic resolution of the atomic 3D structures formed by ground and excited conformational states in an RNA dynamic ensemble
Knowing the 3D structures formed by the various conformations populating the RNA free-
energy landscape, their relative abundance, and kinetic interconversion rates is required to …
energy landscape, their relative abundance, and kinetic interconversion rates is required to …
An RNA excited conformational state at atomic resolution
Sparse and short-lived excited RNA conformational states are essential players in cell
physiology, disease, and therapeutic development, yet determining their 3D structures …
physiology, disease, and therapeutic development, yet determining their 3D structures …
Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA
L Baronti, I Guzzetti, P Ebrahimi, S Friebe Sandoz… - Nature, 2020 - nature.com
MicroRNAs (miRNAs) regulate the levels of translation of messenger RNAs (mRNAs). At
present, the major parameter that can explain the selection of the target mRNA and the …
present, the major parameter that can explain the selection of the target mRNA and the …
Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction
Biomolecules form dynamic ensembles of many inter-converting conformations which are
key for understanding how they fold and function. However, determining ensembles is …
key for understanding how they fold and function. However, determining ensembles is …
N-terminal domain of polypyrimidine-tract binding protein is a dynamic folding platform for adaptive RNA recognition
FF Damberger, M Krepl, R Arora, I Beusch… - Nucleic Acids …, 2024 - academic.oup.com
The N-terminal RNA recognition motif domain (RRM1) of polypyrimidine tract binding protein
(PTB) forms an additional C-terminal helix α3, which docks to one edge of the β-sheet upon …
(PTB) forms an additional C-terminal helix α3, which docks to one edge of the β-sheet upon …
[HTML][HTML] On the specificity of the recognition of m6A-RNA by YTH reader domains
J Widmer, A Vitalis, A Caflisch - Journal of Biological Chemistry, 2024 - Elsevier
Most processes of life are the result of polyvalent interactions between macromolecules,
often of heterogeneous types and sizes. Frequently, the times associated with these …
often of heterogeneous types and sizes. Frequently, the times associated with these …
Exposing hidden high-affinity RNA conformational states
NI Orlovsky, HM Al-Hashimi, TG Oas - Journal of the American …, 2019 - ACS Publications
RNA recognition frequently results in conformational changes that optimize intermolecular
binding. As a consequence, the overall binding affinity of RNA to its binding partners …
binding. As a consequence, the overall binding affinity of RNA to its binding partners …