Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution
Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …
Lexis and grammar of mitochondrial RNA processing in trypanosomes
Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …
health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast …
Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing
In Trypanosoma brucei, the editosome, composed of RNA-editing substrate-binding
complex (RESC) and RNA-editing catalytic complex (RECC), orchestrates guide RNA …
complex (RESC) and RNA-editing catalytic complex (RECC), orchestrates guide RNA …
Assembly and annotation of the mitochondrial minicircle genome of a differentiation-competent strain of Trypanosoma brucei
S Cooper, ES Wadsworth, T Ochsenreiter… - Nucleic acids …, 2019 - academic.oup.com
Kinetoplastids are protists defined by one of the most complex mitochondrial genomes in
nature, the kinetoplast. In the sleeping sickness parasite Trypanosoma brucei, the …
nature, the kinetoplast. In the sleeping sickness parasite Trypanosoma brucei, the …
KREH1 RNA helicase activity promotes utilization of initiator gRNAs across multiple mRNAs in trypanosome RNA editing
Mitochondrial U-indel RNA editing in kinetoplastid protozoa is directed by trans-acting
gRNAs and mediated by a holoenzyme with associated factors. Here, we examine the …
gRNAs and mediated by a holoenzyme with associated factors. Here, we examine the …
Single-molecule morphology of topologically digested olympic networks
S Ramakrishnan, Z Chen, YAG Fosado, L Tubiana… - PRX Life, 2024 - APS
The kinetoplast DNA (kDNA) is the archetype of a two-dimensional Olympic network,
composed of thousands of DNA minicircles and found in the mitochondrion of certain …
composed of thousands of DNA minicircles and found in the mitochondrion of certain …
Blastocrithidia nonstop mitochondrial genome and its expression are remarkably insulated from nuclear codon reassignment
DA Afonin, ES Gerasimov… - Nucleic acids …, 2024 - academic.oup.com
The canonical stop codons of the nuclear genome of the trypanosomatid Blastocrithidia
nonstop are recoded. Here, we investigated the effect of this recoding on the mitochondrial …
nonstop are recoded. Here, we investigated the effect of this recoding on the mitochondrial …
Genomics of Trypanosomatidae: where we stand and what needs to be done?
Trypanosomatids are easy to cultivate and they are (in many cases) amenable to genetic
manipulation. Genome sequencing has become a standard tool routinely used in the study …
manipulation. Genome sequencing has become a standard tool routinely used in the study …
Organization of minicircle cassettes and guide RNA genes in Trypanosoma brucei
S Cooper, ES Wadsworth, A Schnaufer, NJ Savill - Rna, 2022 - rnajournal.cshlp.org
Mitochondrial DNA of protists of order Kinetoplastida comprises thousands of interlinked
circular molecules arranged in a network. There are two types of molecules called …
circular molecules arranged in a network. There are two types of molecules called …
High throughput sequencing revolution reveals conserved fundamentals of U‐indel editing
SL Zimmer, RM Simpson… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Among Euglenozoans, mitochondrial RNA editing occurs in the diplonemids and in the
kinetoplastids that include parasitic trypanosomes. Yet U‐indel editing, in which open …
kinetoplastids that include parasitic trypanosomes. Yet U‐indel editing, in which open …