Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Fibrotic diseases are a significant global burden for which there are limited treatment
options. The effector cells of fibrosis are activated fibroblasts called myofibroblasts, a highly …

Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease
for which our pathophysiological understanding is still limited and specific prevention and …

Metabolic syndrome (MS) is a highly prevalent condition in patients affected by heart failure
(HF); however, it is still unclear whether, in the setting of cardiac dysfunction, it represents an …

Obesity and osteoporosis are two alarming health disorders prominent among middle and
old age populations, and the numbers of those affected by these two disorders are …

Obesity is a global epidemic that greatly increases risk for developing cardiovascular
disease and type II diabetes. Sex differences in the obese phenotype are well established in …

Obesity is a global pandemic with a huge burden on the healthcare system. Obesity is not
only linked to the development of risk factors for atherosclerotic vascular disease but also …

Obesity is a worldwide epidemic affecting over 13% of the adult population and is defined by
an excess of body fat that predisposes comorbidities. It is considered a multifactorial disease …

Diabetic cardiomyopathy entails a serious cardiac dysfunction induced by alterations in
structure and contractility of the myocardium. This pathology is initiated by changes in …

Background: Although nutritional, metabolic and cardiovascular abnormalities are
commonly seen in experimental studies of obesity, it is uncertain whether these effects result …