Cancer is one of the world's most burdensome diseases, with increasing prevalence and a
high mortality rate threat. Tumor recurrence and metastasis due to treatment resistance are …

Epithelial–mesenchymal transition (EMT) is a fundamental process driving cancer
metastasis, transforming non-motile cells into a motile population that migrates to distant …

Abstract Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are
ubiquitously present membrane-bound efflux pumps that distribute endo-and xenobiotics …

Background Although DHFR gene amplification has long been known as a major
mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed …

A current clinical challenge in cancer is multidrug resistance (MDR) mediated by ABC
transporters. Breast cancer resistance protein (BCRP) or ABCG2 transporter is one of the …

Plant‐based combination strategies have been widely considered in cancer therapy to
attenuate chemotherapeutics side effects. The anti‐leukemic effect of the whole ginger …

急性淋巴细胞白血病(acute lymphoblastic leukemia, ALL) 在儿童血液肿瘤中发病率最高,
占比约为所有儿童癌症的三分之一. 随着治疗方案的不断优化和我国医疗保障水平的持续提升 …

Background and purpose: One strategy to overcome methotrexate (MTX) resistance in acute
lymphoblastic leukemia is suppressing MDR1 expression. It has been proved Astragalus …

Purpose Appropriate sub-classification of leukemia according to the immunophenotypic
characteristics of the malignant cells may improve therapeutic strategies. The aim of this …

This study aimed to figure out how microRNA (miR)-411-3p's impacts on methotrexate
(MTX)'s cellular uptake and cytotoxicity in acute lymphoblastic leukaemia (ALL) CEM-C1 …