Redefining autoimmune disorders' pathoetiology: implications for mood and psychotic disorders' association with neurodegenerative and classical autoimmune …

G Anderson, AF Almulla, RJ Reiter, M Maes - Cells, 2023 - mdpi.com
Although previously restricted to a limited number of medical conditions, there is a growing
appreciation that 'autoimmune'(or immune-mediated) processes are important aspects of a …

Brain mitochondrial bioenergetics in genetic neurodevelopmental disorders: focus on Down, Rett and fragile X syndromes

D Valenti, RA Vacca - International Journal of Molecular Sciences, 2023 - mdpi.com
Mitochondria, far beyond their prominent role as cellular powerhouses, are complex cellular
organelles active as central metabolic hubs that are capable of integrating and controlling …

Modulating Nitric Oxide: Implications for Cytotoxicity and Cytoprotection

I Belenichev, O Popazova, N Bukhtiyarova… - Antioxidants, 2024 - mdpi.com
Despite the significant progress in the fields of biology, physiology, molecular medicine, and
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …

Betulinic acid in the treatment of breast cancer: Application and mechanism progress

H Mu, Y Sun, B Yuan, Y Wang - Fitoterapia, 2023 - Elsevier
Betulinic acid (BA) is a pentacyclic triterpene compound, which can be obtained by
separation, chemical synthesis and biotransformation. BA has excellent biological activities …

Nanodrug Delivery Systems for Myasthenia Gravis: Advances and Perspectives

J Huang, Z Yan, Y Song, T Chen - Pharmaceutics, 2024 - mdpi.com
Myasthenia gravis (MG) is a rare chronic autoimmune disease caused by the production of
autoantibodies against the postsynaptic membrane receptors present at the neuromuscular …

[HTML][HTML] Synergistic Effects of Korean Mistletoe and Apple Peel Extracts on Muscle Strength and Endurance

YG Kang, J Kwon, S Kwon, AR Kim - Nutrients, 2024 - mdpi.com
Muscular strength and endurance are vital for physical fitness. While mistletoe extract has
shown efficacy in significantly increasing muscle strength and endurance, its accessibility is …

Defective macrophage efferocytosis in advanced atherosclerotic plaque and mitochondrial therapy

W Li, Y Huang, J Liu, Y Zhou, H Sun, Y Fan, F Liu - Life Sciences, 2024 - Elsevier
Atherosclerosis (AS) is a chronic inflammatory disease primarily affecting large and medium-
sized arterial vessels, characterized by lipoprotein disorders, intimal thickening, smooth …

[HTML][HTML] Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 sensitizes cisplatin lung anticancer therapy …

R Amorim, CC Magalhães, S Benfeito, F Cagide… - Biochemical …, 2024 - Elsevier
The pharmacological interest in mitochondria is very relevant since these crucial organelles
are involved in the pathogenesis of multiple diseases, such as cancer. In order to modulate …

Metabolic reprogramming contributes to radioprotection by protein kinase Cδ

AM Ohm, T Affandi, JA Reisz, MC Caino… - Journal of Biological …, 2023 - ASBMB
Loss of protein kinase Cδ (PKCδ) activity renders cells resistant to DNA damaging agents,
including irradiation; however, the mechanism (s) underlying resistance is poorly …

A High-Throughput Screening of a Natural Products Library for Mitochondria Modulators

E Makinde, L Ma, GD Mellick, Y Feng - Biomolecules, 2024 - mdpi.com
Mitochondria, the energy hubs of the cell, are progressively becoming attractive targets in
the search for potent therapeutics against neurodegenerative diseases. The pivotal role of …