As the organ with the highest demand for oxygen, the brain has a poor tolerance to ischemia
and hypoxia. Despite severe ischemia/hypoxia induces the occurrence and development of …

Remote ischemic preconditioning (RIPC) is an intrinsic protective phenomenon in which 3 to
4 interspersed cycles of non-fatal regional ischemia followed by reperfusion to the remote …

Oxygen is both vital and toxic to life. Molecular oxygen is the most used substrate in the
human body and is required for several hundred diverse biochemical reactions. The …

Remote ischemic conditioning (RIC) is a promising therapeutic approach for ischemic stroke
patients. It has been proven that RIC reduces infarct size and improves functional outcomes …

Background Remote ischemic postconditioning (RIPostC) may protect the brain from
ischemia/reperfusion (I/R) injury. The association between RIPostC and obesity has not yet …

Remote ischaemic conditioning (RIC) becomes an attractive strategy for the endogenous
stimulation of mechanisms protecting neurons against ischaemia. Although the processes …

The inflammation and coagulopathy during coronavirus disease (COVID-19) impairs the
efficiency of the current stroke treatments. Remote ischaemic conditioning (RIC) has shown …

The successful implementation of remote ischaemic conditioning as a clinical
neuroprotective strategy requires a thorough understanding of its basic principles, which can …

Shortage of oxygen and nutrients in the brain induces the release of glutamate and ATP that
can cause excitotoxicity and contribute to neuronal and glial damage. Our understanding of …

Ischaemic tolerance induced by remote ischaemic conditioning (RIC) has been extensively
demonstrated in several preclinical models of cerebral ischaemia. However, animals with …