Abstract The KV1. 3 voltage‐gated potassium ion channel is involved in many physiological
processes both at the plasma membrane and in the mitochondria, chiefly in the immune and …

Introduction: The effective treatment of autoimmune diseases remains a challenge. Voltage-
gated potassium Kv1. 3 channels, which are expressed in lymphocytes, are a new …

A novel peptide, Cm39, was identified in the venom of the scorpion Centruroides
margaritatus. Its primary structure was determined. It consists of 37 amino acid residues with …

Ion channels are transmembrane proteins that form aqueous pores driving ions through the
plasma membrane in favor of an electrochemical gradient. Thus, voltage-dependent …

Since the discovery of the Kv1. 3 voltage-gated K+ channel in human T cells in 1984, ion
channels are considered crucial elements of the signal transduction machinery in the …

Upregulation of the voltage-gated potassium channel KV1. 3 is implicated in a range of
autoimmune and neuroinflammatory diseases, including rheumatoid arthritis, psoriasis …

Rheumatoid arthritis (RA) is a serious autoimmune disease that has severe impacts on both
the wellbeing of patients and the economy of the health system. Similar to many …

Human galectin-3 (h Gal-3) is involved in a variety of biological processes and is implicated
in wide range of diseases. As a result, targeting h Gal-3 for clinical applications has become …

Abstract Kv1. 3 K+ channels play a central role in the regulation of T cell activation and Ca
2+ signaling under physiological and pathophysiological conditions. Peptide toxins targeting …

Margatoxin (MgTx) is a high-affinity blocker of voltage-gated potassium (Kv) channels. It
inhibits Kv1. 1–Kv1. 3 ion channels in picomolar concentrations. This toxin is widely used to …