In the clinic, chimeric antigen receptor–modified T (CAR T) cell therapy is frequently
associated with life-threatening cytokine-release syndrome (CRS) and neurotoxicity …

Ex vivo manipulations of autologous patient's cells or gene-engineered cell therapeutics
have allowed the development of cell and gene therapy approaches to treat otherwise …

Abstract Purpose of Review The treatment landscape of multiple myeloma is rapidly
changing; however, despite improvement in patients' survival, it still remains a largely …

The possibility of editing complex genomes in a targeted fashion has revolutionized basic
research as well as biomedical and biotechnological applications in the last 5 years. The …

Introduction: Adoptive cell therapy (ACT) is becoming an increasingly successful and
widespread form of treatment for different types of cancer. Compared to chemotherapy or …

Lentiviral vectors (LVs) developed in the past two decades for research and pre-clinical
purposes have entered clinical trials with remarkable safety and efficacy performances …

Despite recent advances in reducing therapy-related mortality after allogeneic stem cell
transplantation (alloSCT) relapse remains the major cause of treatment failure and little …

Recent advances in human genome science have paved the way to a new class of human
gene therapies based on gene editing, with the potential to provide a long-lasting curative …

The cytokine release syndrome (CRS) is described as a collection of potentially life-
threatening symptoms associated with a plethora of infections, such as haemorrhagic fever …

One of the safest and most efficient treatments for monogenic diseases affecting the
hematopoietic system is gene therapy using lentiviral vectors (LVs) and gammaretroviral …