Cushing's disease: the burden of illness

R Pivonello, MC De Martino, M De Leo, C Simeoli… - Endocrine, 2017 - Springer
Cushing's syndrome is caused by prolonged exposure to elevated cortisol levels. The most
common form of endogenous Cushing's syndrome is Cushing's disease, which results from …

Long-Term Consequences of Cushing Syndrome: A Systematic Literature Review

S Puglisi, AME Perini, C Botto, F Oliva… - The Journal of Clinical …, 2024 - academic.oup.com
It is held that the condition of endogenous chronic hypersecretion of cortisol (Cushing
syndrome, CS), causes several comorbidities, including cardiovascular and metabolic …

Basomedial amygdala mediates top-down control of anxiety and fear

A Adhikari, TN Lerner, J Finkelstein, S Pak… - Nature, 2015 - nature.com
Anxiety-related conditions are among the most difficult neuropsychiatric diseases to treat
pharmacologically, but respond to cognitive therapies. There has therefore been interest in …

Pituitary adenomas and neuropsychological status: a systematic literature review

M Pertichetti, S Serioli, F Belotti, D Mattavelli… - Neurosurgical …, 2020 - Springer
Neurocognitive and psychological dysfunctions associated with pituitary adenomas (PAs)
are clinically relevant, though probably under-reported. The aim of the current review is to …

Psychiatric symptoms in patients with Cushing's syndrome: prevalence, diagnosis and management

A Santos, E Resmini, JC Pascual, I Crespo, SM Webb - Drugs, 2017 - Springer
Cushing's syndrome (CS) results from chronic exposure to cortisol excess, produced by the
adrenal cortex. Hypercortisolism predisposes to psychiatric and neurocognitive disorders …

[HTML][HTML] Quality of life in patients with Cushing's disease

A Santos, E Resmini, MA Martínez Momblán… - Frontiers in …, 2019 - frontiersin.org
Cushing's disease (and by extension, Cushing's syndrome) is a rare disease due to a
chronic cortisol excess, which usually has an important impact on quality of life (QoL). It can …

[HTML][HTML] Hair cortisol concentration as a biomarker of sleep quality and related disorders

N El Mlili, H Ahabrach, O Cauli - Life, 2021 - mdpi.com
Cortisol is the end product of the hypothalamic-pituitary-adrenal (HPA) axis, and its
production is increased mainly in stressful situations or in chronic disorders accompanied by …

Reduced sleep quality and depression associate with decreased quality of life in patients with pituitary adenomas

SM Leistner, J Klotsche, C Dimopoulou… - European Journal of …, 2015 - academic.oup.com
Objectives Several studies reported decreased quality of life (QoL) and sleep as well as
increased rates of depression for patients with pituitary adenomas. Our aim was to explore to …

[HTML][HTML] Patient-reported outcomes in refractory hormone-producing pituitary adenomas: an unmet need

VR van Trigt, ICM Pelsma, NR Biermasz - Pituitary, 2023 - Springer
Purpose To describe quality and outcomes of patient-reported outcome (PRO) measures
(PROMs) used in patients with refractory hormone-producing pituitary adenomas, and to …

[HTML][HTML] Hyperactivity of hypothalamic-pituitary-adrenal axis due to dysfunction of the hypothalamic glucocorticoid receptor in sigma-1 receptor knockout mice

T Di, S Zhang, J Hong, T Zhang, L Chen - Frontiers in Molecular …, 2017 - frontiersin.org
Sigma-1 receptor knockout (σ1R-KO) mice exhibit a depressive-like phenotype. Because
σ1R is highly expressed in the neuronal cells of hypothalamic paraventricular nuclei (PVN) …