ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity
C Anastassopoulou, Z Gkizarioti, GP Patrinos… - Human genomics, 2020 - Springer
Background The emergence of the novel coronavirus in Wuhan, Hubei Province, China, in
December 2019 marked the synchronization of the world to a peculiar clock that is counting …
December 2019 marked the synchronization of the world to a peculiar clock that is counting …
APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort
The novel respiratory disease COVID-19 produces varying symptoms, with fever, cough, and
shortness of breath being common. In older adults, we found that preexisting dementia is a …
shortness of breath being common. In older adults, we found that preexisting dementia is a …
Dementia and outcomes from coronavirus disease 2019 (COVID-19) pneumonia: a systematic review and meta-analysis
TI Hariyanto, C Putri, J Arisa, RFV Situmeang… - Archives of Gerontology …, 2021 - Elsevier
Background The number of positive and death cases from coronavirus disease 2019
(COVID-19) is still increasing until now. One of the most prone individuals, even in normal …
(COVID-19) is still increasing until now. One of the most prone individuals, even in normal …
Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample
Dementia is more prevalent in Blacks than in Whites, likely due to a combination of
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …
ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank
We previously reported that the ApoE e4e4 genotype was associated with COVID-19 test
positivity (odds ratio [OR]= 2.31, 95% CI: 1.65–3.24, p= 1.19× 10− 6)(1) in the UK Biobank …
positivity (odds ratio [OR]= 2.31, 95% CI: 1.65–3.24, p= 1.19× 10− 6)(1) in the UK Biobank …
Dementia is a predictor for mortality outcome from coronavirus disease 2019 (COVID-19) infection
TI Hariyanto, C Putri, RFV Situmeang… - European Archives of …, 2021 - Springer
Coronavirus disease 2019 (COVID-19), a pandemic disease, has caused a significant
impact on the economic, health, and social aspect. The disease has caused over 500,000 …
impact on the economic, health, and social aspect. The disease has caused over 500,000 …
Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort
Inflammatory protein biomarkers induced by immune responses have been associated with
cognitive decline and the pathogenesis of Alzheimer's disease (AD). Here, we investigate …
cognitive decline and the pathogenesis of Alzheimer's disease (AD). Here, we investigate …
Genetic associations for two biological age measures point to distinct aging phenotypes
Biological age measures outperform chronological age in predicting various aging
outcomes, yet little is known regarding genetic predisposition. We performed genome‐wide …
outcomes, yet little is known regarding genetic predisposition. We performed genome‐wide …
Race, APOE genotypes, and cognitive decline among middle-aged urban adults
Abstract Background Associations of Apolipoprotein (APOE) ε 2 or ε 4 (APOE 2 or APOE 4)
dosages with cognitive change may differ across racial groups. Methods Longitudinal data …
dosages with cognitive change may differ across racial groups. Methods Longitudinal data …