Recent advances in the synthesis of hydantoins: the state of the art of a valuable scaffold

L Konnert, F Lamaty, J Martinez, E Colacino - Chemical Reviews, 2017 - ACS Publications
The review highlights the hydantoin syntheses presented from the point of view of the
preparation methods. Novel synthetic routes to various hydantoin structures, the advances …

Mechanochemical preparation of hydantoins from amino esters: application to the synthesis of the antiepileptic drug phenytoin

L Konnert, B Reneaud, RM de Figueiredo… - The Journal of …, 2014 - ACS Publications
The eco-friendly preparation of 5-and 5, 5-disubstituted hydantoins from various amino ester
hydrochlorides and potassium cyanate in a planetary ball-mill is described. The one-pot/two …

Mechanistic insights on the mechanosynthesis of phenytoin, a WHO essential medicine

F Puccetti, S Lukin, K Užarević… - … A European Journal, 2022 - Wiley Online Library
In recent years, mechanochemistry has enriched the toolbox of synthetic chemists, enabling
faster and more sustainable access to new materials and existing products, including active …

Cascade reactions of nitrogen-substituted isocyanates: a new tool in heterocyclic chemistry

JF Vincent-Rocan, RA Ivanovich, C Clavette… - Chemical …, 2016 - pubs.rsc.org
In contrast to normal C-substituted isocyanates, nitrogen-substituted isocyanates (N-
isocyanates) are rare. Their high reactivity and amphoteric/ambident nature has prevented …

Regioselective multicomponent sequential synthesis of hydantoins

F Olimpieri, MC Bellucci, T Marcelli… - Organic & Biomolecular …, 2012 - pubs.rsc.org
The development of new practical and green methods for the synthesis of small heterocycles
is an attractive area of research due to the well-known potential of heterocyclic small …

A Cascade Synthesis of Aminohydantoins Using In Situ‐Generated N‐Substituted Isocyanates

JF Vincent‐Rocan, C Clavette, K Leckett… - … A European Journal, 2015 - Wiley Online Library
Nitrogen‐substituted isocyanates are rarely utilized but powerful building blocks for the
development of cascade reactions in heterocyclic synthesis. These reactive amphoteric …

Synthesis of hydantoins from N‐Boc protected amino acid derived amides using polymer‐supported PPh3/CBr4 as a reagent

G Tasic, N Mitrovic, M Simic… - Journal of …, 2024 - Wiley Online Library
Hydantoin derivatives are versatile structural motifs found in natural products and various
compounds with different biological or other properties. Due to their importance in both …

Three-component, one-pot sequential synthesis of glyco-hydantoin conjugates

MC Bellucci, A Ghilardi, A Volonterio - Organic & Biomolecular …, 2011 - pubs.rsc.org
The development of new methods for linking sugars to heterocycles and peptides is an
attractive area of research because glyco-conjugates play important roles in biology and …

[图书][B] Amino Acids: Insights and Roles in Heterocyclic Chemistry: Volume 2: Hydantoins, Thiohydantoins, and 2, 5-Diketopiperazines

Z Wang - 2023 - taylorfrancis.com
This is the second volume of a first-of-its-kind four-volume book set that provides readers
with up-to-date information on α-amino acids, the potential challenges in working with α …

A novel facile approach to obtain phenytoin and thiophenytoin using new deep eutectic solvent-like mixtures of urea, thiourea, and KOH

EV Khovrenko, VY Baula, VV Shtrykova… - Chemistry of …, 2024 - Springer
A novel facile approach to obtain phenytoin and thiophenytoin using new deep eutectic
solvent-like mixtures of urea, thiourea, and KOH | Chemistry of Heterocyclic Compounds Skip …