Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

Cyclic peptides are promising scaffolds for drug development, attributable in part to their
increased conformational order compared to linear peptides. However, when optimizing the …

Macrocyclic compounds are of growing interest because of their natural existence, their
interesting biological, physicochemical properties, and potential applications in medicine. 1 …

This compendium focuses on functionalised sugar amino acids (SAAs) and their 3-to 6-
membered nitrogen heterocyclic and carbocyclic analogues. The main benefit of using SAAs …

Gramicidin S (GS), one of the oldest commercially used peptide antibiotics, is known for its
robust antibacterial activity against both Gram-positive and Gram-negative bacterial strains …

The rise of antibiotic resistant bacteria requires unconventional strategies toward efficient
chemotherapeutic agents, preferably with alternative mechanisms of action. The bacterial …

Primary amine groups of branched poly (ethylene imine)(PEI) were functionalized with
quaternary ammonium groups, alkyl chains of different length, allylic and benzylic groups in …

Sugar amino acids (SAAs) are carbohydrate derivatives bearing both amino and carboxylic
acid functionalities. SAAs are very versatile conformationally biased building blocks …

Naturally occurring cyclic antimicrobial peptides (AMPs) such as tyrocidine A (Tyrc A) and
gramicidin S (GS) are appealing targets for the development of novel antibiotics. However …

Viele Proteine entfalten ihre biologische Aktivität über kleine exponierte
Oberflächenregionen aus gefalteten Peptiden mit wohldefinierten dreidimensionalen …