The complement system is an important part of the innate immune defence. It contributes not
only to local inflammation, removal and killing of pathogens, but it also assists in shaping of …

Complement activation is associated with common rheumatic diseases such as systemic
lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic vasculitis. Evidence …

The innate immune system consists of a cellular and a humoral arm. Pentraxins (eg, the
short pentraxin C reactive protein and the long pentraxin PTX3) are key components of the …

Pentraxins are a family of multimeric pattern-recognition proteins highly conserved in
evolution. Based on the primary structure of the subunit, the pentraxins are divided into two …

Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations derived
from the involvement of multiple organs including the kidneys, joints, nervous system and …

Deficiency in C1q, the recognition component of the classical complement cascade and a
pattern recognition receptor involved in apoptotic cell clearance, leads to lupus-like …

Complement protein C1q, the recognition molecule of the classical pathway, performs a
diverse range of complement and non-complement functions. It can bind various ligands …

The complement system was traditionally known as an effector arm of humoral immunity.
Today we also recognize it as a main element of the innate immune system. In blood and …

Efficient apoptotic cell clearance is critical for maintenance of tissue homeostasis, and to
control the immune responses mediated by phagocytes. Little is known about the molecules …

The complement system is an ancient and evolutionarily conserved effector system
comprising in mammals over 50 circulating and membrane bound proteins. Complement …