The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

Nitric oxide (NO) is an endogenously produced signaling molecule that regulates blood flow
and platelet activation. However, intracellular and intravascular diffusion of NO are limited by …

Numerous methods are available for measurement of nitrate (NO− 3). However, these
assays can either be time consuming or require specialized equipment (eg, nitrate …

Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

Background—Intravascular red cell hemolysis impairs nitric oxide (NO)–redox homeostasis,
producing endothelial dysfunction, platelet activation, and vasculopathy. Red blood cell …

Nitric oxide (NO⋅), a potentially toxic molecule, has been implicated in a wide range of
biological functions. Details of its biochemistry, however, remain poorly understood. The …

There has been confusion as to what role (s) nitric oxide (NO) has in different physiological
and pathophysiological mechanisms. Some studies imply that NO has cytotoxic properties …