Mechanoregulation of YAP and TAZ in cellular homeostasis and disease progression
Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …
homeostasis. During organ development and tissue injury repair, compressive and tensional …
Cellular mechanotransduction: from tension to function
F Martino, AR Perestrelo, V Vinarský, S Pagliari… - Frontiers in …, 2018 - frontiersin.org
Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …
Static and dynamic: evolving biomaterial mechanical properties to control cellular mechanotransduction
The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …
biological, and chemical signals to embraced cells. Increasing evidence suggests that …
[HTML][HTML] Substrate curvature as a cue to guide spatiotemporal cell and tissue organization
SJP Callens, RJC Uyttendaele, LE Fratila-Apachitei… - Biomaterials, 2020 - Elsevier
Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …
Actin dynamics, architecture, and mechanics in cell motility
L Blanchoin, R Boujemaa-Paterski… - Physiological …, 2014 - journals.physiology.org
Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …
drives a large range of cellular processes including polarity establishment, morphogenesis …
Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest
Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely
unclear. Here, acute perturbations (∼ 1 h) to actomyosin stress or ECM elasticity cause …
unclear. Here, acute perturbations (∼ 1 h) to actomyosin stress or ECM elasticity cause …
[HTML][HTML] Micro and Nanofabrication methods to control cell-substrate interactions and cell behavior: A review from the tissue engineering perspective
Cell-substrate interactions play a crucial role in the design of better biomaterials and
integration of implants with the tissues. Adhesion is the binding process of the cells to the …
integration of implants with the tissues. Adhesion is the binding process of the cells to the …
Mechanosensing by the nucleus: From pathways to scaling relationships
The nucleus is linked mechanically to the extracellular matrix via multiple polymers that
transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some …
transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some …
[HTML][HTML] Anisotropic scaffolds for peripheral nerve and spinal cord regeneration
The treatment of long-gap (> 10 mm) peripheral nerve injury (PNI) and spinal cord injury
(SCI) remains a continuous challenge due to limited native tissue regeneration capabilities …
(SCI) remains a continuous challenge due to limited native tissue regeneration capabilities …
The physical and biochemical properties of the extracellular matrix regulate cell fate
The extracellular matrix is a complex network of hydrated macromolecular proteins and
sugars that, in concert with bound soluble factors, comprise the acellular stromal …
sugars that, in concert with bound soluble factors, comprise the acellular stromal …