Systemic mechanisms of necrotic cell debris clearance
S Schuermans, C Kestens, PE Marques - Cell Death & Disease, 2024 - nature.com
Necrosis is an overarching term that describes cell death modalities caused by (extreme)
adverse conditions in which cells lose structural integrity. A guaranteed consequence of …
adverse conditions in which cells lose structural integrity. A guaranteed consequence of …
Understanding the role of cGAS-STING signaling in ischemic stroke: a new avenue for drug discovery
C Chauhan, RK Kaundal - Expert Opinion on Drug Discovery, 2023 - Taylor & Francis
Introduction Ischemic stroke is a significant global health challenge with limited treatment
options. Neuroinflammation, driven by microglial activation, plays a critical role in stroke …
options. Neuroinflammation, driven by microglial activation, plays a critical role in stroke …
Secreted mammalian DNases protect against systemic bacterial infection by digesting biofilms
Extracellular DNase DNASE1L3 maintains tolerance to self-DNA in humans and mice,
whereas the role of its homolog DNASE1 remains controversial, and the overall function of …
whereas the role of its homolog DNASE1 remains controversial, and the overall function of …
Targeting NETs using dual-active DNase1 variants
H Englert, J Göbel, D Khong, M Omidi… - Frontiers in …, 2023 - frontiersin.org
Background Neutrophil Extracellular Traps (NETs) are key mediators of immunothrombotic
mechanisms and defective clearance of NETs from the circulation underlies an array of …
mechanisms and defective clearance of NETs from the circulation underlies an array of …
[HTML][HTML] GWAS shows the genetics behind cell-free DNA and highlights the importance of p. Arg206Cys in DNASE1L3 for non-invasive testing
The properties of cell-free DNA (cfDNA) are intensely studied for their potential as non-
invasive biomarkers. We explored the effect of common genetic variants on the …
invasive biomarkers. We explored the effect of common genetic variants on the …
Origin and significance of the human DNase repertoire
G Mori, D Delfino, P Pibiri, C Rivetti, R Percudani - Scientific Reports, 2022 - nature.com
The human genome contains four DNase1 and two DNase2 genes. The origin and
functional specialization of this repertoire are not fully understood. Here we use genomics …
functional specialization of this repertoire are not fully understood. Here we use genomics …
A novel DNase assay reveals low DNase activity in severe asthma
AR Charbit, MA Liegeois… - … of Physiology-Lung …, 2024 - journals.physiology.org
Secreted deoxyribonucleases (DNases), such as DNase-I and DNase-IL3, degrade
extracellular DNA, and endogenous DNases have roles in resolving airway inflammation …
extracellular DNA, and endogenous DNases have roles in resolving airway inflammation …
Deficiency of macrophage-derived Dnase1L3 causes lupus-like phenotypes in mice
M Engavale, CJ Hernandez, A Infante… - Journal of Leukocyte …, 2023 - academic.oup.com
Systemic lupus erythematosus (SLE) is an autoimmune disease caused by environmental
factors and loss of key proteins, including the endonuclease Dnase1L3. Dnase1L3 absence …
factors and loss of key proteins, including the endonuclease Dnase1L3. Dnase1L3 absence …
The Effect of Cell-Free DNA from Blood Serum of Mice with Metastatic Melanoma on Enhancement of Oncogenic Properties of Melanoma Cells
AA Filatova, LA Alekseeva, IA Savin, AV Sen'kova… - Biochemistry …, 2023 - Springer
Currently, a significant increase in the levels of circulating cell-free DNA (cfDNA) in the blood
of patients is considered as a generally recognized marker of the development of …
of patients is considered as a generally recognized marker of the development of …
[HTML][HTML] The mouse epididymal amyloid matrix is a mammalian counterpart of a bacterial biofilm
C Myers, GR Atkins, J Villarreal, RB Sutton… - Iscience, 2024 - cell.com
The mouse epididymis is a long tubule connecting the testis to the vas deferens. Its primary
functions are to mature spermatozoa into motile and fertile cells and to protect them from …
functions are to mature spermatozoa into motile and fertile cells and to protect them from …