Cu (I)-catalyzed click chemistry in glycoscience and their diverse applications
Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …
1, 2, 3-Triazole-based sequence-defined oligomers and polymers
X Wang, X Zhang, S Ding - Polymer Chemistry, 2021 - pubs.rsc.org
Mimicking nature to create polymers with well-defined sequences and precise chain lengths
for multitudinous applications is an increasingly attractive but challenging field. In the …
for multitudinous applications is an increasingly attractive but challenging field. In the …
Easily functionalized and readable sequence-defined polytriazoles
X Zhang, F Gou, X Wang, Y Wang, S Ding - ACS Macro Letters, 2021 - ACS Publications
Developing sequence-defined skeletons that could be conveniently characterized and
functionalized with diverse side groups is attractive but challenging. Here we report one …
functionalized with diverse side groups is attractive but challenging. Here we report one …
Novel benzimidazole derived naphthalimide triazoles: synthesis, antimicrobial activity and interactions with calf thymus DNA
YL Luo, K Baathulaa, VK Kannekanti, CH Zhou… - Science China …, 2015 - Springer
A novel series of benzimidazole derived naphthalimide triazoles and some corresponding
triazoliums have been successfully synthesized and characterized by 1 H NMR, 13 C NMR …
triazoliums have been successfully synthesized and characterized by 1 H NMR, 13 C NMR …
Modified nucleosides, nucleotides and nucleic acids via click azide-alkyne cycloaddition for pharmacological applications
D Perrone, E Marchesi, L Preti, ML Navacchia - Molecules, 2021 - mdpi.com
The click azide= alkyne 1, 3-dipolar cycloaddition (click chemistry) has become the
approach of choice for bioconjugations in medicinal chemistry, providing facile reaction …
approach of choice for bioconjugations in medicinal chemistry, providing facile reaction …
New 1-(Spiro [chroman-2, 1′-cycloalkan]-4-yl)-1H-1, 2, 3-Triazoles: Synthesis, QTAIM/MEP analyses, and DNA/HSA-binding assays
FS Stefanello, YG Kappenberg, A Ketzer… - Journal of Molecular …, 2021 - Elsevier
This study synthesized and characterized the DNA/HSA properties of a new series of 12
examples of 4-(alkyl/aryl)-1-(spiro [chroman-2, 1′-cycloalkan]-4-yl)-1H-1, 2, 3-triazoles …
examples of 4-(alkyl/aryl)-1-(spiro [chroman-2, 1′-cycloalkan]-4-yl)-1H-1, 2, 3-triazoles …
ClickSeq: replacing fragmentation and enzymatic ligation with click-chemistry to prevent sequence chimeras
E Jaworski, A Routh - Next Generation Sequencing: Methods and …, 2018 - Springer
We recently reported a fragmentation-free method for the synthesis of Next-Generation
Sequencing libraries called “ClickSeq” that uses biorthogonal click-chemistry in place of …
Sequencing libraries called “ClickSeq” that uses biorthogonal click-chemistry in place of …
Triazole-modified nucleic acids for the application in bioorganic and medicinal chemistry
D Baraniak, J Boryski - Biomedicines, 2021 - mdpi.com
This review covers studies which exploit triazole-modified nucleic acids in the range of
chemistry and biology to medicine. The 1, 2, 3-triazole unit, which is obtained via click …
chemistry and biology to medicine. The 1, 2, 3-triazole unit, which is obtained via click …
Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-C-Methyl Pyrimidine-Modified Oligonucleotides
Although judicious use of chemical modifications has contributed to the success of nucleic
acid therapeutics, poor systemic stability remains a major hurdle. The introduction of …
acid therapeutics, poor systemic stability remains a major hurdle. The introduction of …
Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA
P Kumar, AH El-Sagheer, L Truong… - Chemical …, 2017 - pubs.rsc.org
Oligonucleotides containing internal triazole–3′-LNA linkages bind to complementary RNA
with similar affinity and specificity to unmodified oligonucleotides, and significantly better …
with similar affinity and specificity to unmodified oligonucleotides, and significantly better …