Novel coronavirus (COVID-19 or 2019-nCoV or SARS-CoV-2), which suddenly emerged in
December 2019 is still haunting the entire human race and has affected not only the …

For almost 40 years, difluoromethylene phosphonates have proven to be versatile molecular
tools in biochemical studies owing to their close resemblance to naturally occurring …

Chiral phosphine-containing skeletons are important motifs in bioactive natural products,
pharmaceuticals, chiral catalysts, and ligands. Herein, we report a general and modular …

C‐reactive protein (CRP) is an early‐stage acute phase protein and highly upregulated in
response to inflammatory reactions. We recently identified a novel mechanism that leads to …

Transition‐metal‐catalyzed asymmetric carbon− carbon bond formation to forge
phosphonates with an α‐chiral carbon center through C (sp3)− C (sp3) and C (sp2)− C (sp3) …

Remdesivir (RDV) is the only US Food and Drug Administration (FDA)-approved drug for
treating COVID-19. However, RDV can only be given by intravenous route, and there is a …

Remdesivir (GS-5734) is a monophenol, 2-ethylbutylalanine phosphoramidate prodrug of a
1′-cyano-4-aza-7, 9-dideazaadenosine C-nucleoside (GS-441524) that is FDA approved …

To address the continued rise of multi-drug-resistant microorganisms, the development of
novel drugs with new modes of action is urgently required. While humans biosynthesize the …

Antiviral drugs such as Remdesivir (Veklury), Nirmatrelvir with Ritonavir (Paxlovid),
Azvudine, and Molnupiravir (Lagevrio) can reduce the risk for severe and fatal Coronavirus …

Prodrugs are derivatives with superior properties compared with the parent active
pharmaceutical ingredient (API), which undergo biotransformation after administration to …