Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

[HTML][HTML] The spread of antibiotic resistance to humans and potential protection strategies

D Ding, B Wang, X Zhang, J Zhang, H Zhang… - Ecotoxicology and …, 2023 - Elsevier
Antibiotic resistance is currently one of the greatest threats to human health. Widespread
use and residues of antibiotics in humans, animals, and the environment can exert selective …

Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases

G Ianiro, M Punčochář, N Karcher, S Porcari… - Nature Medicine, 2022 - nature.com
Fecal microbiota transplantation (FMT) is highly effective against recurrent Clostridioides
difficile infection and is considered a promising treatment for other microbiome-related …

Antibiotic resistome from the One-Health perspective: understanding and controlling antimicrobial resistance transmission

DW Kim, CJ Cha - Experimental & molecular medicine, 2021 - nature.com
The concept of the antibiotic resistome was introduced just over a decade ago, and since
then, active resistome studies have been conducted. In the present study, we describe the …

Understanding the impact of antibiotic perturbation on the human microbiome

DJ Schwartz, AE Langdon, G Dantas - Genome medicine, 2020 - Springer
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses
that performs essential functions for immune development, pathogen colonization …

Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health

M Fassarella, EE Blaak, J Penders, A Nauta, H Smidt… - Gut, 2021 - gut.bmj.com
The human gut microbiome is a complex ecosystem, densely colonised by thousands of
microbial species. It varies among individuals and depends on host genotype and …

Deciphering the mobility and bacterial hosts of antibiotic resistance genes under antibiotic selection pressure by metagenomic assembly and binning approaches

R Zhao, K Yu, J Zhang, G Zhang, J Huang, L Ma… - Water research, 2020 - Elsevier
The presence of antibiotics can exert significant selection pressure on the emergence and
spread of antibiotic resistance genes (ARGs) and antibiotic resistant bacteria (ARB) …

Good microbes, bad genes? The dissemination of antimicrobial resistance in the human microbiome

A Crits-Christoph, HA Hallowell, K Koutouvalis… - Gut …, 2022 - Taylor & Francis
ABSTRACT A global rise in antimicrobial resistance among pathogenic bacteria has proved
to be a major public health threat, with the rate of multidrug-resistant bacterial infections …

Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics

JH Jo, CP Harkins, NH Schwardt, JA Portillo… - Science translational …, 2021 - science.org
Although systemic antibiotics are critical in controlling infections and reducing morbidity and
mortality, overuse of antibiotics is presumed to contribute to negative repercussions such as …

Antibiotic-induced gut dysbiosis and barrier disruption and the potential protective strategies

H Duan, L Yu, F Tian, Q Zhai, L Fan… - Critical reviews in food …, 2022 - Taylor & Francis
The oral antibiotic therapies administered widely to people and animals can cause gut
dysbiosis and barrier disruption inevitably. Increasing attention has been directed toward …